Functional divergence between evolutionary related LuxG and Fre oxidoreductases of luminous bacteria [PDF]
In luminous bacteria NAD(P)H:flavin-oxidoreductases LuxG and Fre there are homologous enzymes that could provide a luciferase with reduced flavin.
Evgenia A. Zykova +3 more
core +1 more source
Peumus boldus: Revealing the Pharmaceutical Potential of the Chilean Forest
P. boldus emerge as a promising yet underexplored source of bioactive compounds. Current evidence highlights antioxidant, anti‐inflammatory, antimicrobial, and cytoprotective activities associated with their unique phytochemical profile. This review integrates chemical composition, biological properties, proposed molecular mechanisms, and safety ...
Marta Rodríguez‐Ceballos +8 more
wiley +1 more source
Review of NAD(P)H-dependent oxidoreductases: Properties, engineering and application [PDF]
NAD(P)H-dependent oxidoreductases catalyze the reduction or oxidation of a substrate coupled to the oxidation or reduction, respectively, of a nicotinamide adenine dinucleotide cofactor NAD(P)H or NAD(P)+.
Mordaka, Paweł M. +7 more
core +2 more sources
Nanocatalysts Containing Direct Electron Transfer-Capable Oxidoreductases: Recent Advances and Applications [PDF]
Direct electron transfer (DET)-capable oxidoreductases are enzymes that have the ability to transfer/receive electrons directly to/from solid surfaces or nanomaterials, bypassing the need for an additional electron mediator.
Dagys, Marius +5 more
core +2 more sources
Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella +2 more
wiley +1 more source
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari +3 more
wiley +1 more source
Aldehyde-Functional Diblock Copolymer Nano-objects via RAFT Aqueous Dispersion Polymerization
We report the rational design of aldehyde-functional sterically stabilized diblock copolymer nano-objects in aqueous solution via polymerization-induced self-assembly.
Mark J. Smallridge (1416730) +2 more
core +1 more source
Imine Reductase‐Mediated Regio‐ and Stereoselective Reductive Amination of Diamines
Imine reductases (IREDs) have been employed as biocatalysts for the regioselective modification of diamines via reductive amination. The use of racemic diamines resulted in both regio‐ and enantio‐selective reductive amination via kinetic resolution. The application of this methodology has been demonstrated on a preparative scale by the synthesis of a ...
Arnau Rué Casamajo +7 more
wiley +1 more source
Iron and Other Metal Ions in Human Health and Disease
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
Human β‐Cell Dedifferentiation and Diabetes
Human β‐cell dedifferentiation is inversely associated with HOMA‐β and occurs in Type 2 diabetes, Type 3c diabetes, and age‐related diabetes, potentially before hyperglycemia develops. Progressive loss of β‐cell identity is accompanied by dedifferentiation and transdifferentiation, suggesting that reversing these cell‐state changes may help restore ...
Jiajun Sun, Jinsook Son, Qidi Wang
wiley +1 more source

