Results 71 to 80 of about 30,391 (259)
Case Reports in Genetics, 2018 Activating mutations in thyrotropin receptor (TSHR) have been previously described in the context of nonautoimmune hyperthyroidism and thyroid adenomas. We describe, for the first time, a mutation in TSHR contributing to follicular thyroid carcinoma (FTC)
James Blackburn +8 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Efficient cationic gold(I)‐catalyzed intermolecular cyclopropanation of 7‐alkynylnorbornadiene derivatives has been developed. This methodology offers the synthesis of a new class of norbornene derivatives in high yield with excellent diastereoselectivity.
Kento Ishida +3 more
wiley +1 more source
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, EarlyView.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source
Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, EarlyView.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source
Burning Properties of Combined Glued Laminated Timber
FireThis study delved into the combustion properties of combined glulam bonded using polyurethane (PUR) and resorcinol-phenol-formaldehyde (RPF) adhesives.
Tomáš Kytka +5 more
doaj +1 more source
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
Chemistry – A European Journal, EarlyView.This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua +3 more
wiley +1 more source
Лесной журналAn assessment of carbon pools in the components of the aboveground phytomass of the tree and shrub layer of the small-leaved stage of succession is presented for thickets of gray alder (Alnus incana L.) and goat willow (Salix caprea L.) with an admixture
Denis N. Klevtsov +4 more
doaj +1 more source