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Diethylaminobenzaldehyde Is a Covalent, Irreversible Inactivator of ALDH7A1 [PDF]

ACS Chemical Biology, 2015
There is growing interest in aldehyde dehydrogenases (ALDHs) because of their overexpression in cancer stem cells and the ability to mediate resistance to cancer drugs. Here, we report the first crystal structure of an aldehyde dehydrogenase complexed with the inhibitor 4-diethylaminobenzaldehyde (DEAB).
Min Luo +3 more
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Impact of missense mutations in the ALDH7A1 gene on enzyme structure and catalytic function

Biochimie, 2020
Certain mutations in the ALDH7A1 gene cause pyridoxine-dependent epilepsy (PDE), an autosomal recessive metabolic disease characterized by seizures, and in some cases, intellectual disability. The mutational spectrum of PDE is vast and includes over 70 missense mutations.
David A. Korasick, John J. Tanner
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Atypical pyridoxine dependent epilepsy resulting from a new homozygous missense mutation, in ALDH7A1 [PDF]

Seizure, 2018
Pyridoxine dependent epilepsy (PDE) is a rare autosomal recessive neurometabolic disorder. In the classical form, seizures are observed within the first month of life, while in the atypical form seizures appear later in life, sometimes as late as at the age of 3 years of life.
Ziyad S. Haidar +5 more
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Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse

Theranostics, 2021
Rationale: The activity of aldehyde dehydrogenase 7A1 (ALDH7A1), an enzyme that catalyzes the lipid peroxidation of fatty aldehydes was found to be upregulated in pancreatic ductal adenocarcinoma (PDAC). ALDH7A1 knockdown significantly reduced tumor formation in PDAC. We raised a question how ALDH7A1 contributes to cancer progression.
Jae-Seon Lee +11 more
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Aldehyde dehydrogenase 7 family member A1 (ALDH7A1) [PDF]

Science-Business eXchange, 2010

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Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity [PDF]

Chemico-Biological Interactions, 2011
Mammalian aldehyde dehydrogenase 7A1 (ALDH7A1) is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. In previous studies, we have
Chad Brocker +3 more
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Global gene expression profiling of individual human oocytes and embryos demonstrates heterogeneity in early development [PDF]

, 2013
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals.
Brison, Daniel R +4 more
core +8 more sources

Evidence of Mutational Heterogeneity of the ALDH7A1 Gene in Tunisian Families: Molecular and Insilico Investigations [PDF]