Results 1 to 10 of about 26,703 (153)

Should PNPO Deficiency Be Treated In Utero? Clinical Findings From Prenatal Pyridoxine Therapy [PDF]

JIMD Reports
Pyridox(am)ine‐5′‐phosphate oxidase (PNPO) deficiency is characterized by early‐onset epileptic encephalopathy refractory to standard antiseizure medications.
Chloé de Puyraimond, Samia Pichard, Muriel Girard, Julian Delanne, Laurence Faivre, Apolline Imbard, Amandine Baurand, Jean‐François Benoist, Philippa B. Mills, Peter T. Clayton, Manuel Schiff   +10 more
doaj   +2 more sources

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study

Integrative Cancer Therapies, 2022
Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving
Li Xiaozhe MD, Chen Meilan MD, Huang Beihui MD, Liu Junru MD, Gu Jingli MD, Kuang Lifen MD, Li Juan MD   +6 more
doaj   +1 more source

Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy – A cross sectional study

Saudi Pharmaceutical Journal, 2023
Background: Diabetic Peripheral Neuropathy is one of the most important and significantly prevalent microvascular complications of Diabetes Mellitus. Pyridoxine is a key nutrient for protecting nerve health. The objective of this research is to study the
Moteb Khobrani, Geetha Kandasamy, Rajalakshimi Vasudevan, AbdulAziz Alhossan, Ranadheer Chowdary Puvvada, Praveen Devanandan, Rajeshri Dhurke, Manusri Naredla   +7 more
doaj   +1 more source

Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits

Animal Nutrition, 2021
This study was conducted to evaluate the effect of pyridoxine on the development of hair follicles in Rex rabbits and the underlying molecular mechanism.
Gongyan Liu, Guangmin Cheng, Yongcui Zhang, Shuxia Gao, Haitao Sun, Liya Bai, Shu Li, Yanli Zhu, Chunyang Wang, Fuchang Li   +9 more
doaj   +1 more source

Pyridoxine-dependent and pyridoxine-responsive seizures [PDF]

Developmental Medicine and Child Neurology, 2001
Pyridoxine dependency was one of the first genetically mediated seizure disorders to be recognized. However, the biochemical abnormality and gene locus are still unknown. Knowledge about the condition has come from case reports and small clinical series. However, new features are still being recognized both clinically, as well as more predictably, from
  +6 more sources

The Impacts of Graded Doses of Pyridoxine on the Biomarkers, Aspartate Aminotransferase, lactate Dehydrogenase and Total Antioxidant Capacity in Doxorubicin-Induced Cardiotoxicity in Female Rats

Iraqi Journal of Pharmaceutical Sciences, 2017
:        The aim of the current study was to investigate the possible protective effect of graded doses (5, 10, and 15mg/kg) of pyridoxine hydrochloride intraperitoneally injected against (15mg/kg) doxorubicin-induced cardiotoxicity in female rats ...
Doaa Kadhim Abdul Ridha, Nada Naji Al-Shawi   +1 more
doaj   +3 more sources

Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H + -driven lysosomal pyridoxine exporter

Life Science Alliance, 2023
DIRC2 is an H + -driven lysosomal pyridoxine exporter involved in the regulation of cellular pyridoxine storage. Disrupted in renal carcinoma 2 (DIRC2) has gained interest because of its association with the development of renal cancer and cosegregation ...
Shogo Akino, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa   +3 more
doaj   +1 more source

Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice

Toxicology Reports, 2021
Pyridoxine is a co-factor in many enzymatic reactions and impacts of deficiency have been observed in affected populations. A possible modifying effect of pyridoxine deficiency on benzene toxicity was assessed in male B6C3F1 mice fed either a pyridoxine ...
Chanthana Tangjarukij, Daam Settachan, Judith T. Zelikoff, Panida Navasumrit, Mathuros Ruchirawat   +4 more
doaj   +1 more source

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

Neural Regeneration Research, 2020
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine ...
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung   +6 more
doaj   +1 more source

8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. [PDF]

PLoS ONE, 2017
OBJECTIVESWe report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy.
Rujun Zhang, Navindra Persaud
doaj   +1 more source