Results 41 to 50 of about 6,810 (200)

ROLE OF PYRIDOXINE HYDROCHLORIDE IN THE DEVELOPMENT OF TOLERANCE TO THE TOXIC ACTION OF ISONIAZID IN ANIMALS

open access: yesТуберкулез и болезни лёгких, 2018
The objective of the study: to assess the impact of continuous and course (intermittent) use of pyridoxine hydrochloride in combination with isoniazid on the rate of tolerance development in rats under conditions of a toxicological experiment.Subjects ...
K. I. Usov, T. A. Guskova, G. G. Yushkov
doaj   +1 more source

GCP II inhibition improved several pyridoxine-induced locomotor deficits.

open access: yes, 2014
(a) Walking performance was significantly reduced upon pyridoxine treatment with the control group being significantly different to both pyridoxine treated groups particularly on days 11 and 15.
Barbara S. Slusher (634276)   +3 more
core   +1 more source

Dual‐Function Cosubstrates Enable Threonine Dehydrogenase‐Driven Chemoenzymatic Pyrrole Synthesis

open access: yesAngewandte Chemie International Edition, EarlyView.
Classical Knorr chemistry meets contemporary biocatalysis. Threonine dehydrogenase generates aminoacetone from l‐threonine, which is directly intercepted in a chemoenzymatic Knorr pyrrole synthesis. A dual‐function β‐dicarbonyl substrate serves as both pyrrole precursor and hydride acceptor for integrated NAD+ recycling, affording substituted pyrroles ...
Valentina Jurkaš   +8 more
wiley   +1 more source

Effect of pyridoxine and isonicotinic acid hydrazide on the nervous system during tuberculosis treatment

open access: yesТуберкулез и болезни лёгких, 2018
When treating tuberculosis patients with multi-component chemotherapy it is necessary to use medications in order to manage or minimize side effects. The review presents research findings on the effect of pyridoxine and its derivatives on the nervous ...
Tatyana E. Tyulkova
doaj   +1 more source

Pyridoxine, but not thiamin, improves growth performance of weanling pigs [PDF]

open access: yes, 1997
Two trials were conducted to determine whether pyridoxine or thiamine needs to be added to the diet for weanling pigs. In the first trial, weanling pigs were fed either a control diet or diets containing added thiamin (2.5 or 5.0 g/ton) or pyridoxine (
Goodband, Robert D.   +26 more
core   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

open access: yesAnimal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu   +8 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Insights into the Cardioprotective Effects of Pyridoxine Treatment in Diabetic Rats: A Study on Cardiac Oxidative Stress, Cardiometabolic Status, and Cardiovascular Biomarkers

open access: yesDiagnostics
The aims of this study were to examine the effects of pyridoxine administration on the activities of cardiac antioxidant stress enzymes superoxide dismutase (SOD) and catalase (CAT) and enzyme indicators of cardiometabolic status, lactate and malate ...
Slavica Mutavdzin Krneta   +7 more
doaj   +1 more source

Carboxylate–Probase Catalyzed Favorskii Reaction

open access: yesChemistry – A European Journal, EarlyView.
Stronger together: A combination of a carboxylate catalyst and a silylating agent generates a stronger base catalyst for a metal‐free catalytic addition of alkynes to aldehydes and ketones under chemoselective, O‐silylative conditions. The reaction is proposed to proceed via quaternary ammonium (Q+) cation – acetylide anion ion pairs, with chiral ...
Anton Bannykh   +4 more
wiley   +1 more source

Pyridoxine‐dependent epilepsy: Current perspectives and questions for future research

open access: yesAnnals of the Child Neurology Society, 2023
Pyridoxine‐dependent epilepsy (PDE) was historically defined by a dramatic clinical response to a trial of pyridoxine and the re‐emergence of seizures after withdrawal of pyridoxine.
Curtis R. Coughlin  II   +1 more
doaj   +1 more source

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