Results 31 to 40 of about 33,290 (259)

Pyridoxine for prevention and treatment of PARP inhibitor induced nausea and vomiting

open access: yesGynecologic Oncology Reports, 2019
Poly-ADP ribose polymerase inhibitors (PARPi) are a promising new treatment option for patients with ovarian cancer and are moderately emetogenic. Tolerance of therapy is paramount, and uncontrolled nausea and vomiting may limit use.
Stuart A. Ostby   +2 more
doaj   +1 more source

Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70

open access: yesCells, 2020
Pyridoxine, one of the vitamin B6 vitamers, plays a crucial role in amino acid metabolism and synthesis of monoamines as a cofactor. In the present study, we observed the effects of pyridoxine deficiency on novel object recognition memory.
Hyo Young Jung   +9 more
doaj   +1 more source

Reactions of Pyridoxine [PDF]

open access: yes, 1970
Title: Reactions of Pyridoxine, Author: Frederick J. Rowell, Location: ThodeThe chemistry of pyridoxine has been critically examined with a view to obtaining new intermediates suitable for the systematic degradation of the molecule.
Rowell, Frederick J.
core   +1 more source

Scientific Opinion on the safety and efficacy of vitamin B6 as a feed additive for all animal species

open access: yesEFSA Journal, 2010
Pyridoxine hydrochloride is a form of vitamin B6, an essential micronutrient. It occurs in the body as pyridoxal 5’‐phosphate. It serves as a coenzyme in transamination, decarboxylation and desamination reactions.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores

open access: yesDiagnostics, 2019
Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk ...
Rima Obeid   +2 more
doaj   +1 more source

Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. [PDF]

open access: yesPLoS ONE, 2014
Pyridoxine is used as a supplement for treating conditions such as vitamin deficiency as well as neurological disorders such as depression, epilepsy and autism.
Michelle C Potter   +3 more
doaj   +1 more source

Comparing between Pyridoxine hydrochloride, Doxylamine Succinate/Pyridoxine Hydrochloride and Ondansetron for Treatment of Nausea and Vomiting in Pregnant Females [PDF]

open access: yesThe Egyptian Family Medicine Journal
Background: Nausea and vomiting of pregnancy (NVP) is a common gestational condition, NVP affecting up to 80% of the pregnant women and are the third leading causes of maternal hospitalization during pregnancy.
taghreed farahat   +4 more
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

open access: yesAdvanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li   +9 more
wiley   +1 more source

Variable treatment response in a patient with pyridoxal N phosphate oxidase (PNPO) deficiency- understanding the paradox

open access: yesEpilepsy & Behavior Reports, 2020
A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication.
Smilu Mohanlal   +3 more
doaj   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

open access: yesAdvanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko   +8 more
wiley   +1 more source

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