Results 51 to 60 of about 36,291 (209)

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source

Investigating the Role of Myopathy Markers Ex-pression (Creatine Kinase, Aldolase, INF-γ and TNF-α) Following the Use of Chemotherapy Drugs in Children with Leukemia [PDF]

Iranian South Medical Journal
Background: Acute lymphoblastic leukemia (ALL) is one of the most common childhood malignancies with a prevalence of 40 per million children under 15 years old.
Samireh Ghafouri, Roya Salehi kahyesh, Shahram Rajaee Behbahani, Shiva Razie, Arash Alghasi, Mohammad Hosein Faramarzi   +5 more
doaj  

Real world data of cabozantinib in patients with hepatocellular carcinoma: Focusing on dose setting and modification

Cancer Medicine
Aim To investigate the outcomes of cabozantinib in patients with unresectable hepatocellular carcinoma (uHCC), focusing on dose setting and modification. Methods We retrospectively analyzed 34 Japanese patients who received cabozantinib for uHCC.
Hironao Okubo, Hitoshi Ando, Shunsuke Nakamura, Yusuke Takasaki, Koichi Ito, Yuka Fukuo, Kenichi Ikejima, Hiroyuki Isayama   +7 more
doaj   +1 more source

Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis

Malaria Journal, 2012
Background The malaria aldolase is widely used as rapid diagnostic test (RDT), but the efficacy in aspect of its serological effectiveness in diagnosis is not known.
Kim Jung-Yeon, Kim Hyung-Hwan, Shin Hyun-ll, Sohn Youngjoo, Kim Hyuck, Lee Sang-Wook, Lee Won-Ja, Lee Hyeong-Woo   +7 more
doaj   +1 more source

Delayed diagnosis of hereditary fructose intolerance presenting as chronic lean steatosis in an adolescent

JPGN Reports, EarlyView.
Abstract Hereditary fructose intolerance (HFI) typically presents in infancy with acute metabolic crisis upon the introduction of fructose. We report a case of a 13‐year‐old female with chronic abdominal pain, short stature, and persistent mild transaminitis.
Alexandra Hurlock, Melissa Lah, Hannah Sue Hyaduck, Jean P. Molleston, Chaowapong Jarasvaraparn   +4 more
wiley   +1 more source

Poor prognostic factors for relapse of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies after combination therapy

Frontiers in Immunology
IntroductionThis study aimed to identify useful clinical indicators for predicting the relapse of interstitial lung disease (ILD) complicated with anti-aminoacyl-tRNA synthetase (ARS) antibodies (anti-ARS-ILD), being treated with prednisolone and ...
Shogo Matsuda, Takuya Kotani, Katsumasa Oe, Ayana Okazaki, Takao Kiboshi, Takayasu Suzuka, Yumiko Wada, Takeshi Shoda, Tohru Takeuchi   +8 more
doaj   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Diagnostic value of the isoenzymatic index of lactate dehydrogenase in blood serum in a special process for training cadet pilots

Frontiers in Physiology
ObjectivesSpecial aerial gymnastics instruments (SAGI) are permanent elements of specialist training for cadet pilots. Appropriate physical activity and fitness are essential for performing the tasks of military pilots.
Zbigniew Wochyński, Ireneusz Majsterek, Joanna Gerszon, Radosław Wojtczak, Jacek Kabziński, Jan Błaszczyk, Krzysztof A. Sobiech, Ewa Jabłońska, Wioletta Ratajczak-Wrona   +8 more
doaj   +1 more source