Results 51 to 60 of about 41,156 (268)

Real world data of cabozantinib in patients with hepatocellular carcinoma: Focusing on dose setting and modification

Cancer Medicine
Aim To investigate the outcomes of cabozantinib in patients with unresectable hepatocellular carcinoma (uHCC), focusing on dose setting and modification. Methods We retrospectively analyzed 34 Japanese patients who received cabozantinib for uHCC.
Hironao Okubo, Hitoshi Ando, Shunsuke Nakamura, Yusuke Takasaki, Koichi Ito, Yuka Fukuo, Kenichi Ikejima, Hiroyuki Isayama   +7 more
doaj   +1 more source

Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis

Malaria Journal, 2012
Background The malaria aldolase is widely used as rapid diagnostic test (RDT), but the efficacy in aspect of its serological effectiveness in diagnosis is not known.
Kim Jung-Yeon, Kim Hyung-Hwan, Shin Hyun-ll, Sohn Youngjoo, Kim Hyuck, Lee Sang-Wook, Lee Won-Ja, Lee Hyeong-Woo   +7 more
doaj   +1 more source

RBD‐SD1 Nanoparticle Vaccines From DPP4‐Using Merbecoviruses Elicit a Cross‐Reactive Antibody Response but Limited Cross‐Protective Immunity

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann, Jeong Soo Lee, Tong Wang, Augustine Duffy, Janie E. Rogers, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +9 more
wiley   +1 more source

Poor prognostic factors for relapse of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies after combination therapy

Frontiers in Immunology
IntroductionThis study aimed to identify useful clinical indicators for predicting the relapse of interstitial lung disease (ILD) complicated with anti-aminoacyl-tRNA synthetase (ARS) antibodies (anti-ARS-ILD), being treated with prednisolone and ...
Shogo Matsuda, Takuya Kotani, Katsumasa Oe, Ayana Okazaki, Takao Kiboshi, Takayasu Suzuka, Yumiko Wada, Takeshi Shoda, Tohru Takeuchi   +8 more
doaj   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Diagnostic value of the isoenzymatic index of lactate dehydrogenase in blood serum in a special process for training cadet pilots

Frontiers in Physiology
ObjectivesSpecial aerial gymnastics instruments (SAGI) are permanent elements of specialist training for cadet pilots. Appropriate physical activity and fitness are essential for performing the tasks of military pilots.
Zbigniew Wochyński, Ireneusz Majsterek, Joanna Gerszon, Radosław Wojtczak, Jacek Kabziński, Jan Błaszczyk, Krzysztof A. Sobiech, Ewa Jabłońska, Wioletta Ratajczak-Wrona   +8 more
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

PCR primers for an aldolase-B intron in acanthopterygian fishes

BMC Evolutionary Biology, 2001
Background Nuclear DNA sequences provide genetic information that complements studies using mitochondrial DNA. Some 'universal' primer sets have been developed that target introns within protein-coding loci, but many simultaneously amplify introns from ...
Jones William J, Quattro Joseph M, Oswald Kenneth J   +2 more
doaj   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice

Obesity, EarlyView.
ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo, Yi Zhang, Ariana Zoe Diaz Portalatin, Gregory C. Henderson   +3 more
wiley   +1 more source