Results 71 to 80 of about 36,291 (209)

Mannich Reaction With Pyridoxal 5′‐Phosphate Dependent Decarboxylative Aldolase for Synthesis of Noncanonical α‐Amino Acids

ChemistryEurope
Functionalized benzosultam and sulfonamide derivatives represent privileged pharmacophores in medicinal chemistry. However, noncanonical amino acids (ncAAs) featuring benzosultam side chains remain underexplored for peptide therapeutics, despite ...
Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao   +4 more
doaj   +1 more source

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source

The Carboxyl-terminal Structure of Rabbit Liver Aldolase (Aldolase B)

Journal of Biological Chemistry, 1970
Abstract The amino acid residues in the carboxyl-terminal region of fructose diphosphate aldolase isolated from fresh rabbit liver are -(Gly,Phe,Leu,Ala,Thr2,Ser2)-Tyr. This differs from the carboxyl-terminal structure in aldolase isolated from tissue which had been frozen and thawed.
A G, Lacko, L W, Brox, R W, Gracy, B L, Horecker   +3 more
openaire   +2 more sources

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung, Nitha Aima Muntu, Ulrika Reistam, Jonathan A. Kirk, Marcus Ståhlberg   +4 more
wiley   +1 more source

Enzimas séricas e eletromiografia em doenças Neuromusculares: estudo comparativo de 817 casos

Arquivos de Neuro-Psiquiatria, 1995
Foram estudadas as enzimas séricas (creatinaquinase, desidrogenase láctica, aldolase, aspartato e alanina aminotransferase) de 817 pacientes e eletromiografias (EMG) de 588 casos de portadores de doenças neuromusculares.
Lineu Cesar Werneck
doaj   +1 more source

Graph identification of proteins in tomograms (GRIP‐Tomo) 2.0: Topologically aware classification for proteins

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Cryo‐electron tomography (cryo‐ET) enables structural characterization of biomolecules under near‐native conditions. Existing approaches for interpreting the resulting three‐dimensional volumes are computationally expensive and have difficulty interpreting density associated with small proteins/complexes.
Chengxuan Li, August George, Reece Neff, Doo Nam Kim, Trevor Moser, Kate Baldwin, Malio Nelson, Arsam Firoozfar, James E. Evans, Margaret S. Cheung   +9 more
wiley   +1 more source

Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions

Frontiers in Bioengineering and Biotechnology, 2019
Most of biochemical and mutagenesis studies performed with L-threonine aldolases were done with respect to natural activity, the cleavage of L-threonine and sometimes L-β-phenylserine.
Kateryna Fesko
doaj   +1 more source

Different involvement for aldolase isoenzymes in kidney glucose metabolism: Aldolase B but not aldolase A colocalizes and forms a complex with FBPase

Journal of Cellular Physiology, 2004
AbstractThe expression of aldolase A and B isoenzyme transcripts was confirmed by RT‐PCR in rat kidney and their cell distribution was compared with characteristic enzymes of the gluconeogenic and glycolytic metabolic pathway: fructose‐1,6‐bisphosphatase (FBPase), phosphoenol pyruvate carboxykinase (PEPCK), and pyruvate kinase (PK).
Yanez, AJ, Ludwig, HC, Bertinat, R, Spichiger, C, Gatica, R, Berlien, G, Leon, O, Brito, M, Concha, II, Slebe, JC   +9 more
openaire   +4 more sources

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source