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Aldose Reductase Involvement in EMT: Emerging Insights and Current Proposed Molecular Mechanisms [PDF]
BiologyAldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) family and plays a variety of roles in many metabolic and physiological processes.
Gemma Sardelli +4 more
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An Investigation of 5-Halogenated N-Indolylsulfonyl-2-fluorophenol Derivatives as Aldose Reductase Inhibitors [PDF]
MedicinesBackground/Objectives: Diabetes mellitus is a group of chronic metabolic disorders characterized by persistent hyperglycemia. Aldose reductase, the first enzyme in the polyol pathway, plays a key role in the onset of long-term diabetic complications ...
Antonios Kousaxidis +3 more
doaj +2 more sources
Plumbagin Protects Diabetogenic Cataract Formation by Mitigating Lens Aldose Reductase and Oxidative Stress [PDF]
Journal of PharmacopunctureObjectives: The polyol pathway plays an important pathophysiological role in diabetic-related ocular complications, including cataracts, one of the major causes of ocular blindness.
Apurva Yadav +4 more
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Investigating the Inhibitory Potential of Flavonoids against Aldose Reductase: Insights from Molecular Docking, Dynamics Simulations, and gmx_MMPBSA Analysis [PDF]
Current Issues in Molecular BiologyDiabetes mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia, with aldose reductase playing a critical role in the pathophysiology of diabetic complications.
Muhammad Yasir +5 more
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications [PDF]
Frontiers in BioinformaticsBackgroundDiabetes remains a leading cause of morbidity and mortality due to various complications induced by hyperglycemia. Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic ...
Miriam E. L. Gakpey +10 more
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Tạp chí Khoa học và Công nghệAldose reductase is a crucial component of the polyol pathway and catalyzes the NADPH-dependent reduction of glucose to sorbitol. The high activity of Aldose reductase is involved in the development and pathophysiology of diabetes complications ...
Thanh Hoa Tran +3 more
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Spiro Hydantoin Aldose Reductase Inhibitors
Journal of Medicinal Chemistry, 1988 Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of diabetes mellitus. Spiro hydantoins derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens.
R, Sarges +3 more
openaire +3 more sources
Biology, 2022 The inhibition of aldose reductase is considered as a strategy to counteract the onset of both diabetic complications, upon the block of glucose conversion in the polyol pathway, and inflammation, upon the block of 3-glutathionyl-4-hydroxynonenal ...
Francesco Balestri +8 more
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JRST: Jurnal Riset Sains dan Teknologi, 2022 Neuropati diabetes merupakan salah satu komplikasi yang diakui berhubungan dengan meningkatnya stres oksidatif. Penyebab stres oksidatif dapat dicegah dengan menghambat enzim aldose reductase.
Nawfal Imanudin +2 more
doaj +1 more source