Results 171 to 180 of about 16,654 (227)

Borate-Stabilized Transformation of C6 Aldose to C4 Aldose

ACS Catalysis, 2017
Highly efficient transformations of biomass-derived sugars into various valuable chemicals are of topical interest. Tetrose with a four-carbon bone is the root of most of biomass-derived C4 products, but its extreme instability obstructs the blossoming of C4 products presently.
Yueer Yan, Lei Feng, Gang Li, Shaoying Lin, Zhen Sun, Yahong Zhang, Yi Tang   +6 more
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Electrochemical aldose detection with PQQ-dependent aldose dehydrogenase: Dissertation

1995
In this work an enzyme electrode was constructed for amperometric determination of xylose and glucose. The electrode was based on the pyrroloquinoline quinone (PQQ)-dependent membrane-bound aldose dehydrogenase (ALDH) from Gluconobacter oxydans. PQQ-dependent enzymes are particularly suitable for amperometric detection of analytes, since they are ...
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The Aldose Reductase Controversy

Diabetes, 1994
ext to the debate as to whether chronic hyperglycemia is the primary cause of the late vascular complications of diabetes, the longest running controversy among researchers and clinicians studying this disease is the role of the sorbitol pathway, particularly its initial enzymatic step, the reduction of glucose to sorbitol by aldose reductase in the ...
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Rhodium-Catalyzed Decarbonylation of Aldoses

The Journal of Organic Chemistry, 2007
A catalytic procedure is described for decarbonylation of unprotected aldoses to afford alditols with one less carbon atom. The reaction is performed with the rhodium complex Rh(dppp)2Cl in a refluxing diglyme-DMA solution. A slightly improved catalyst turnover is observed when a catalytic amount of pyridine is added.
Rune Nygaard, Monrad, Robert, Madsen
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Intrinsic Inhibition of Aldose Reductase

Journal of Ocular Pharmacology and Therapeutics, 2001
The development of aldose reductase inhibitors for the treatment of diabetic complications, such as cataract and retinopathy, has been of intense interest in the pharmaceutical community for the last 20 years. To date, aldose reductase inhibitors have been synthetically developed from leads obtained from in vitro screening studies.
P F, Kador, G, Sun, V K, Rait, L, Rodriguez, Y, Ma, K, Sugiyama   +5 more
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Aldose dehydrogenase-modified carbon paste electrodes as amperometric aldose sensors

Analytica Chimica Acta, 1995
A biosensor using pyrroloquinoline quinone-dependent aldose dehydrogenase (ALDH) as a biological component was developed and used for the measurement of the aldose sugars xylose and glucose. Different immobilization methods for ALDH in carbon paste were studied.
Marko-Varga, György, Gorton, Lo, Smolander, Maria   +3 more
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The aldose reductase inhibitor site

Metabolism, 1986
Evidence linking the enzyme aldose reductase (alditol:NADP+ oxidoreductase, EC 1.1.1.21) to the pathogenesis of several diabetic complications is rapidly mounting. The results of several animal studies combined with preliminary reports of ongoing clinical trials indicate that inhibition of aldose reductase produces a beneficial effect against such ...
P F, Kador, J H, Kinoshita, N E, Sharpless   +2 more
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Immunohistochemical distribution of aldose reductase

The Histochemical Journal, 1982
Aldose reductase (AR) has been purified from canine kidneys, and a monospecific antibody against the enzyme prepared. These antibodies were used in an immunohistochemical test to detect tissue sites of aldose reductase in the dog, a species known to develop diabetic lesions morphologically identical to those seen in diabetic patients. Using this method,
T S, Kern, R L, Engerman
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Aldose reductase inhibitors: Recent developments

1993
Perfect control of blood glucose levels in diabetic patients might ultimately be achieved with islet or pancreas transplants or with an artificial pancreas. However, to achieve such a goal on a large scale, it will be necessary to overcome the formidable safety or efficacy issues attendant with these approaches (see, e.g., [1, 2]).
R, Sarges, P J, Oates
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Aldose reductase inhibitors and cataract

International Ophthalmology, 1991
Blindness in diabetics is largely due to retinopathy and/or cataract. Hyperglycaemia and the duration of diabetes are major risk factors for the development of cataract and retinopathy. This review details some of the reactions of glucose that are relevant to the development of complications, and follows the elucidation of monosaccharide autoxidation ...
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