Results 11 to 20 of about 16,654 (227)

Product Control and Insight into Conversion of C6 Aldose Toward C2, C4 and C6 Alditols in One‐Pot Retro‐Aldol Condensation and Hydrogenation Processes

ChemistryOpen, 2021
Alcohols have a wide range of applicability, and their functions vary with the carbon numbers. C6 and C4 alditols are alternative of sweetener, as well as significant pharmaceutical and chemical intermediates, which are mainly obtained through the ...
Yingshuang Hui, Dr. Yulu Zhan, Wenrong Hou, Lou Gao, Prof. Yahong Zhang, Prof. Yi Tang   +5 more
doaj   +1 more source

Aldose Reductase Inhibitors [PDF]

Journal of Enzyme Inhibition, 2001
Aldose reductase ([EC1.1.1.21]: AR) acts on the first step of the polyol metabolic pathway to catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the pathway in individuals with high blood glucose level is closely related to the onset or progression of diabetic complications.
M, Oka, N, Kato
openaire   +2 more sources

Formation of Three Selected AGEs and their Corresponding Intermediates in Aldose- and Ketose-lysine Systems

eFood, 2020
Advanced Glycation End Products (AGEs) could be formed with α-dicarbonyl compounds as intermediates; however, simultaneous determination of AGES as well as their precursors and intermediates have rarely been mentioned, so as to investigate the reaction ...
Chaoyi Xue, Zhenhua Shi, Zhiyong He, Zhaojun Wang, Fang Qin, Jie Chen, Maomao Zeng   +6 more
doaj   +1 more source

Modulation of aldose reductase activity by aldose hemiacetals [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior.
BALESTRI, FRANCESCO, CAPPIELLO, MARIO, MOSCHINI, ROBERTA, ROTONDO, ROSSELLA, ABATE, MARCO, DEL CORSO, ANTONELLA, MURA, UMBERTO   +6 more
openaire   +2 more sources

Computational Assessment of Xanthones from African Medicinal Plants as Aldose Reductase Inhibitors

Computation, 2022
Diabetes mellitus is a life-threatening non-communicable disease that affects all age groups. Despite the increased attention it has received in recent years, the number of diabetic patients has grown exponentially.
Onikepe Deborah Owoseeni, Rajesh B. Patil, Prajakta M. Phage, Ruth Mosunmola Ogboye, Marcus Durojaye Ayoola, Samson Oluwaseyi Famuyiwa, Felix Olusegun Gboyero, Derek Tantoh Ndinteh, Kolade Olatubosun Faloye   +8 more
doaj   +1 more source

HPLC Separation of All Aldopentoses and Aldohexoses on an Anion-Exchange Stationary Phase Prepared from Polystyrene-Based Copolymer and Diamine: The Effect of NaOH Eluent Concentration

Molecules, 2011
To investigate the separations of all aldopentoses (ribose, arabinose, xylose and lyxose) and aldohexoses (glucose, galactose, allose, altrose, mannose, gulose, idose and talose) on the D6 stationary phase prepared by the reaction of chloromethylated ...
Takako Masuda-Hanada, Kadumi Inoue, Sadao Arai, Yoshihiro Aikawa, Kei-ichi Kitahara   +4 more
doaj   +1 more source

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Molecules, 2021
Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic ...
Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu, Milan Stefek   +5 more
doaj   +1 more source

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

Cardiovascular Diabetology, 2023
Background Cardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase activity is enhanced in hyperglycemic conditions, leading to altered cardiac energy metabolism and ...
Keshav Gopal, Qutuba G. Karwi, Seyed Amirhossein Tabatabaei Dakhili, Cory S. Wagg, Liyan Zhang, Qiuyu Sun, Christina T. Saed, Sai Panidarapu, Riccardo Perfetti, Ravichandran Ramasamy, John R. Ussher, Gary D. Lopaschuk   +11 more
doaj   +1 more source

In silico identification of chemical compounds in Spondias mombin targeting aldose reductase and glycogen synthase kinase 3β to abate diabetes mellitus

Informatics in Medicine Unlocked, 2023
Aldose reductase and glycogen synthase kinase 3β (GSK3β) represent two of the ideal drug targets in diabetes due to their role in the pathogenesis of diabetes. Studies have shown that plant compounds provide therapeutics in diabetes management.
B.O. Ajiboye, T.M. Fagbola, I.M. Folorunso, A.W. Salami, O.N. Aletile, B.A. Akomolede, F.I. Ayemoni, K.I. Akinfemiwa, V.O. Anwo, M.I. Ojeleke, B.E. Oyinloye   +10 more
doaj   +1 more source

Synthesis and Activity of a New Series of(Z)-3-Phenyl-2-benzoylpropenoic Acid Derivatives as Aldose Reductase Inhibitors

Molecules, 2007
During the course of studies directed towards the discovery of novel aldose reductase inhibitors for the treatment of diabetic complications, we synthesized a series of new (Z)-3-phenyl-2-benzoylpropenoic acid derivatives and tested their in vitro ...
Shao-Jie Wang, Ju-Fang Yan, Dong Hao, Xin-Wen Niu, Mao-Sheng Cheng   +4 more
doaj   +1 more source