Results 21 to 30 of about 16,654 (227)

Evaluation of Pharmacokinetic Parameters, Toxicity, and Molecular Docking of Flavonols with Aldose Reductase Enzyme to Find an Effective Compound in Inhibition of this Enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Aldose reductase plays an important role in chronic diabetes and can cause tissue complications. Controlling the activity of aldose reductase provides an important strategy in controlling the complications of diabetes.
Morteza Sadeghi, Mehran Miroliaei
doaj  

Carica papaya Linn. fruit extract inhibited the activities of aldose reductase and sorbitol dehydrogenase: possible mechanism for amelioration of diabetic complications

Future Journal of Pharmaceutical Sciences, 2020
Background Diabetes mellitus is a metabolic disorder which is associated with debilitating complications including eye disease, kidney disorder, and diabetic foot disease.
Mutiu Idowu Kazeem, Ayotomiwa Adeyinka Adeyemi, Abiola Fatimah Adenowo, Mushafau Adewale Akinsanya   +3 more
doaj   +1 more source

Mechanistic Insights into Sugar Racemization and Oxidative Degradation via Fenton and Alkaline Peroxide Systems

Chemistry
This study explores the oxidation and racemization of selected C5 and C6 sugars using hydrogen peroxide (H2O2) in alkaline and Fenton reaction conditions.
Zoltán Köntös, Áron Németh
doaj   +1 more source

Effects of Ingredients Composition on Meat Flavor Prepared with High Temperature Sesame Cake Protein Hydrolysate

Shipin gongye ke-ji
To analyze the effect of the composition of ingredients (Sulfur-containing substance, saccharide) on meat flavor derived from high temperature sesame cake protein hydrolysate (HTSPH), the influence of five sulfides such as cysteine (L-Cys), methionine (L-
Xin LU, Lixia ZHANG, Qiang SUN, Jing YOU, Jinian HUANG   +4 more
doaj   +1 more source

INHIBITORY ACTIVITY OF FLAVONOIDS ON THE LENS ALDOSE REDUCTASE OF HEALTHY AND DIABETIC RATS [PDF]

Acta Medica Iranica, 2006
Aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. Inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses.
M. T. Goodarzi, F. Zal, M. Malakooti, M. R. Safari S. Sadeghian   +3 more
doaj   +1 more source

Aldo keto reductases 1B in endocrinology and metabolism

Frontiers in Pharmacology, 2012
The aldose reductase (human AKR1B1/mouse Akr1b3) has been the focus of many research because of its role in diabetic complications. The starting point of these alterations is the massive entry of glucose in polyol pathway where it is converted into ...
Emilie ePastel, Jean-Christophe ePointud, Fanny eVolat, Antoine eMartinez, Anne-Marie eLefrançois-Martinez   +4 more
doaj   +1 more source

In silico docking studies of aldose reductase inhibitory activity of commercially available flavonoids

Bangladesh Journal of Pharmacology, 2012
The primary objective of this study was to investigate the aldose reductase inhibitory activity of flavonoids using in silico docking studies. In this perspective, flavonoids like biochanin, butein, esculatin, fisetin and herbacetin were selected ...
Arumugam Madeswaran, Muthuswamy Umamaheswari, Kuppusamy Asokkumar, Thirumalaisamy Sivashanmugam, Varadharajan Subhadradevi, Puliyath Jagannath   +5 more
doaj   +1 more source

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

BMC Chemistry, 2021
In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for ...
Mohsinul Mulk Bacha, Humaira Nadeem, Sumera Zaib, Sadia Sarwar, Aqeel Imran, Shafiq Ur Rahman, Hafiz Saqib Ali, Muazzam Arif, Jamshed Iqbal   +8 more
doaj   +1 more source

In Search of Differential Inhibitors of Aldose Reductase

Biomolecules, 2022
Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic aldehydes.
Francesco Balestri, Roberta Moschini, Umberto Mura, Mario Cappiello, Antonella Del Corso   +4 more
doaj   +1 more source

Extracts of Fruits and Plants Cultivated In Vitro of Aristotelia chilensis (Mol.) Stuntz Show Inhibitory Activity of Aldose Reductase and Pancreatic Alpha-Amylase Enzymes

Plants, 2022
Aristotelia chilensis is a plant whose fruit is considered a powerful natural antioxidant. During the last years, some investigations of the fruit have been carried out, finding antioxidant properties in the juice or the phenolic fraction.
Adriana Pineda, Andrea Arenas, Juan Balmaceda, Gustavo E. Zúñiga   +3 more
doaj   +1 more source