Results 41 to 50 of about 16,654 (227)

Docking studies: In silico aldose reductase inhibitory activity of commercially available flavonoids

Bangladesh Journal of Pharmacology, 2012
New drugs for the inhibition of the enzyme aldose reductase are in development and they have to be screened before being considered for preclinical and clinical evaluation.
Muthuswamy Umamaheswari, C. S. Aji, Kuppuswamy Asokkumar, Thirumalaisamy Sivsshanmugam, Varadharajan Subhadradevi, Puliyath Jagannath, Arumugam Madeswaran   +6 more
doaj   +1 more source

Araucaria heterophylla oleogum resin essential oil is a novel aldose reductase and butyryl choline esterase enzymes inhibitor: in vitro and in silico evidence

Scientific Reports, 2023
The essential oil isolated by hydrodistillation of the oleogum resin of Araucaria heterophylla has been analyzed by GC–MS. Twenty-four components accounting to 99.89% of the total detected constituents of this essential oil were identified.
Amal F. Soliman, Mohamed A. Sabry, Gehad Abdelwahab   +2 more
doaj   +1 more source

Phytosulfokine signalling blocks mycotoxin toxicity in Arabidopsis and mediates suppression of cell death activated by bacterial microbe‐associated molecular patterns

New Phytologist, EarlyView.
Summary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Ali O. Alqarni, John M. U. Hamilton, Adrian P. Brown, Stephen Chivasa   +3 more
wiley   +1 more source

Heterogeneous Catalytic Transformations of Saccharides by Sn Lewis Acid: Recent Progress

ChemCatChem, Volume 18, Issue 2, 28 January 2026.
The review addresses recent advances in heterogeneous catalytic transformations of lignocellulosic saccharides by tin‐containing materials. ABSTRACT Carbohydrates have been considered as important renewable substrates which are readily available in large quantities from waste streams.
Irina Delidovich
wiley   +1 more source

Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica (M. indica) and Mucuna urens (M. urens) seeds extracts against some key enzymes (α-amylase, α-glucosidase and aldose reductase) implicated in the
Emmanuel Anyachukwu Irondi, Ganiyu Oboh, Afolabi Akintunde Akindahunsi, Aline Augusti Boligon, Margareth Linde Athayde   +4 more
doaj   +1 more source

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu, Jingsheng Yuan, Shitong Su, Jiaqi Han, Ni Zeng, Yuhan Ma, Nianyong Chen, Tao Lv   +7 more
wiley   +1 more source

Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations

Journal of Chemistry, 2015
Aldose reductase (ALR2), a vital enzyme involved in polyol pathway, has befitted as a novel drug target in antidiabetes drug discovery process. In the present study, the binding mode and pharmacokinetic properties of potential polyphenolic compounds with
Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Sugunadevi Sakkiah, Byoung Ryong Jeong   +4 more
doaj   +1 more source

Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein molecules. Methods: The phytoconstituents of Ficus benghalensis were queried for inhibitors of alpha-glucosidase, also ...
Pukar Khanal, B M Patil
doaj   +1 more source

Structure-Based Virtual Screening for Differential Inhibition of Aldose Reductase, Implicated in Secondary Complications in Diabetes [PDF]

, 2021
Ranvir Singh
openalex   +1 more source

Recent Advances in the Bioactive Compounds of Prunes (Prunus domestica L.) and Their Health Benefits

Food Frontiers, Volume 7, Issue 1, January 2026.
Prunes (Prunus domestica L.) are a functional food rich in diverse bioactive compounds, including polyphenols (such as chlorogenic acid and anthocyanins), polysaccharides, and sorbitol.This review comprehensively synthesizes current research on the nutritional composition and biological activities of prunes, highlighting their multifaceted health ...
Luyang Han, Tiantian Fu, Menglin Zhou, Manxi Wu, Han Yang, Jinping Cao, Jinhu Tian, Chongde Sun, Yaqun Liu, Feifei Gao, Yue Wang   +10 more
wiley   +1 more source