Results 61 to 70 of about 16,654 (227)

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

Herba Polonica, 2022
Introduction: Aldose reductase (AR) is an enzyme that catalyzes the reduction of glucose to sorbitol responsible for the development of diabetic complications like cataracts. Medicinal plants contain several phytocompounds that can inhibit this enzyme.
Daoudi Nour Elhouda, Bouziane Omar, Bouhrim Mohamed, Bnouham Mohamed   +3 more
doaj   +1 more source

Qinggan Mingshi Granules Inhibited Ferroptosis to Treat Diabetic Retinopathy in Mice Through NRF2/GPX4 Axis

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Diabetic retinopathy (DR) is a common microvascular complication of diabetes, which seriously affected the life quality in diabetic patients. Developing novel therapy to improve DR is essential. Qinggan Mingshi granules (QGMS) have been demonstrated with protective effects on DR clinically.
Zhongyong Zhang, Qianqian Jin, Hongmin Zhao, Yingkai Liu, Meng Wang, Zhongqian Han, Jin Wu, Shuquan Lv, Xiaoyun Wang, Wei Chen, Qingjin Wang, Hailong Bai, Yuansong Wang, Weibo Wen   +13 more
wiley   +1 more source

Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Maturation in Aged Mice: A Multitarget Mechanistic Study Using Network Pharmacology and Molecular Simulations

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Mitochondrial dysfunction plays a critical role in ovarian aging and the associated decline in female fertility. Nicotinamide riboside (NR), a vitamin B3 derivative and dietary NAD+ precursor, has shown antiaging potential, yet its molecular mechanisms in ovarian function are not fully understood.
Ningyu Sun, Xiang Cheng, Lu Lu, Wuwen Zhang, Kai Li, Yuanyuan Chen, Yun Li, Chunling Liu, Qinhua Zhang, Ping Yin, Anupama Bose   +10 more
wiley   +1 more source

Effect of Lignin, Humins, and Biomass‐Derived Acids on Kinetics of Catalytic Hydroxymethylfurfural Production during Saccharide Dehydration Reactions

ChemSusChem, Volume 18, Issue 24, December 13, 2025.
(Hemi)celluloses, abundant in lignocellulosic biomass, can be hydrolyzed and dehydrated into furanics like 5‐hydroxymethylfurfural (5‐HMF) and levulinic acid. Despite its potential, 5‐HMF production remains limited by inefficiencies, notably humin formation.
Ana Jakob, Blaž Likozar, Miha Grilc
wiley   +1 more source

Soyasaponins from Zolfino bean as aldose reductase differential inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1).
Francesco Balestri, Marinella De Leo, Carlo Sorce, Mario Cappiello, Luca Quattrini, Roberta Moschini, Carlotta Pineschi, Alessandra Braca, Concettina La Motta, Federico Da Settimo, Antonella Del-Corso, Umberto Mura   +11 more
doaj   +1 more source

Aldosereductase: structure, mechanism of action, biological role and functioning according to normo and hyperglycemia

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2020
The review summarizes the literature on the structure, biological role and mechanism of action of aldose reductase at different blood glucose levels. Aldosereductase is the first enzyme of the sorbitol (polyol) pathway to glucose metabolism.
Y. M. Makukh, T. M. Gryvul, A. Ya. Krasnevich, D. S. Vignan   +3 more
doaj   +1 more source

Recent Progress on Photoelectrochemical Organic Upgrading: A Review from Direct and Indirect Charge Transfer Pathway

Advanced Energy Materials, Volume 15, Issue 48, December 23, 2025.
Photoelectrochemical (PEC) organic upgrading at the anode, coupled with hydrogen evolution at the cathode, presents a promising strategy for enhancing solar energy utilization while simultaneously generating value‐added chemicals. An overview of directional photoanodic conversion of organic substrates is presented, distinctively with an eye to the ...
Cheng Lin, Yoonjun Cho, Kan Zhang, Jong Hyeok Park   +3 more
wiley   +1 more source

Role of aldose reductase C-106T polymorphism among diabetic Egyptian patients with different microvascular complications

American Journal of Experimental and Clinical Research, 2014
The aldose reductase pathway proves that elevated blood glucose promotes cellular dysfunction. The polyol pathway converts excess intracellular glucose into alcohols via activity of the aldose reductase. This enzyme catalyzes the conversion of glucose to
Nermine Hossam Zakaria, Salah Ahmed Marzouk, Abla Ahmed Abou Zeid, Eman Saeed Gharaff   +3 more
doaj   +2 more sources

Promotion of 5‐hydroxymethylfurfural synthesis from glucose over AlCl3 catalyst with choline chloride

AIChE Journal, Volume 71, Issue 12, December 2025.
Abstract Efficient production of 5‐hydroxymethylfurfural (HMF) from glucose was achieved in a water‐methyl isobutyl ketone biphasic solvent system over AlCl3 catalyst, using a green and cheap choline chloride (ChCl) salt as a promoter. An optimized HMF yield of 67% was obtained from 0.6 M glucose over 0.06 M AlCl3 with 3.8 M ChCl addition at 140°C ...
Chencong Ruan, Hero Jan Heeres, Jun Yue
wiley   +1 more source

Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies.
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti   +10 more
doaj   +1 more source