Investigating the Inhibitory Potential of Flavonoids against Aldose Reductase: Insights from Molecular Docking, Dynamics Simulations, and gmx_MMPBSA Analysis [PDF]
Current Issues in Molecular BiologyDiabetes mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia, with aldose reductase playing a critical role in the pathophysiology of diabetic complications.
Muhammad Yasir +5 more
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Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation [PDF]
Cardiovascular Diabetology, 2023 Background Cardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase activity is enhanced in hyperglycemic conditions, leading to altered cardiac energy metabolism and ...
Keshav Gopal +11 more
doaj +3 more sources
In Search of Differential Inhibitors of Aldose Reductase [PDF]
Biomolecules, 2022 Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic aldehydes.
Francesco Balestri +4 more
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Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review [PDF]
BiomedicinesThe escalating global prevalence of diabetes mellitus (DM) over the past two decades has led to a persistent high incidence of diabetic retinopathy (DR), necessitating screening for early symptoms and proper treatment.
Alexandra-Ioana Dănilă +6 more
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Aldose Reductase Involvement in EMT: Emerging Insights and Current Proposed Molecular Mechanisms [PDF]
BiologyAldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) family and plays a variety of roles in many metabolic and physiological processes.
Gemma Sardelli +4 more
doaj +2 more sources
Molecules, 2021 Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic ...
Lucia Kovacikova +5 more
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Aldose reductase inhibitors: 2013-present [PDF]
Expert Opinion on Therapeutic Patents, 2019 Aldose reductase (ALR2) is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status.
Quattrini L., La Motta C.
openaire +4 more sources
An Investigation of 5-Halogenated N-Indolylsulfonyl-2-fluorophenol Derivatives as Aldose Reductase Inhibitors [PDF]
MedicinesBackground/Objectives: Diabetes mellitus is a group of chronic metabolic disorders characterized by persistent hyperglycemia. Aldose reductase, the first enzyme in the polyol pathway, plays a key role in the onset of long-term diabetic complications ...
Antonios Kousaxidis +3 more
doaj +2 more sources
Plumbagin Protects Diabetogenic Cataract Formation by Mitigating Lens Aldose Reductase and Oxidative Stress [PDF]
Journal of PharmacopunctureObjectives: The polyol pathway plays an important pathophysiological role in diabetic-related ocular complications, including cataracts, one of the major causes of ocular blindness.
Apurva Yadav +4 more
doaj +2 more sources
Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications [PDF]
Frontiers in BioinformaticsBackgroundDiabetes remains a leading cause of morbidity and mortality due to various complications induced by hyperglycemia. Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic ...
Miriam E. L. Gakpey +10 more
doaj +2 more sources