Results 101 to 110 of about 182,045 (267)

Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies

Pharmaceuticals
Background: Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication ...
Osama Alharbi, Wael H. Alsaedi, Mosa Alsehli, Saif H. Althagafi, Hussam Y. Alharbi, Yazeed M. Asiri, Ramith Ramu, Mohammed Al-Ghorbani   +7 more
doaj   +1 more source

Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling

Pharmaceuticals
Background/Objectives: Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetic agents that regulate blood glucose by preventing the degradation of active incretin hormones.
Raquel N. S. Roriz, Claudia J. P. Cardozo, Gabriela A. Freire, Caio B. R. Martins, Raimundo Rigoberto B. X. Filho, Landerson Lopes Pereira, Gisele F. P. Rangel, Tiago L. Sampaio, Lyanna R. Ribeiro, Gisele Silvestre Silva, Isabelle Maia, Deysi Viviana Tenazoa Wong, Daniele O. B. Sousa, Ariclécio Cunha de Oliveira, Eduardo Reina, Lidia Moreira Lima, Walter Peláez, Matheus Nunes da Rocha, Márcia Machado Marinho, Hélcio Silva dos Santos, Emmanuel Silva Marinho, Jane Eire Silva Alencar de Menezes, Fátima Regina Mena Barreto Silva, Kirley Marques Canuto, Nylane M. N. Alencar, Marisa Jadna Silva Frederico   +25 more
doaj   +1 more source

Astaxanthin inhibits aldose reductase activity in Psammomys obesus, a model of type 2 diabetes and diabetic retinopathy [PDF]

, 2019
Maha Benlarbi‐Ben Khedher, Khouloud Hajri, Ahmed Dellaa, Basma Baccouche, Imane Hammoum, Nourhène Boudhrioua, Wissal Dhifi, Rafika Ben Chaouacha‐Chekir   +7 more
openalex   +1 more source

Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase [PDF]

Lucia Kováčiková, Sunil Gaikwad, Kristína Almášiová, Ambróz Almássy, Gabriela Addová, Magdaléna Májeková, Gilles Hanquet, Vladimir Dobričić, Andrej Boháč, Milan Štefek   +9 more
openalex   +1 more source

Supplementary Figure 1 from Aldose Reductase Regulates Growth Factor-Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Colon Cancer Cells

, 2023
Ravinder Tammali, Kota V. Ramana, Sharad S. Singhal, Sanjay Awasthi, Satish K. Srivastava   +4 more
openalex   +1 more source

Molecular cloning of cDNA coding for kidney aldose reductase

, 1989
A. García-Pérez, Brian M. Martin, Helen Murphy, Shinichi Uchida, Heini Murer, Benjamin D. Cowley, Jerome S. Handler, Maurice B. Burg   +7 more
openalex   +1 more source

ALTERATIONS OF ALDOSE REDUCTASE ACTIVITY BY INDOLE-3-CARBOXALDEHYDE DERIVATIVES

, 2021
Orçun Erdem Kurşun, Síbel Süzen, Özlem Yıldırım   +2 more
openalex   +2 more sources

1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors

, 2013
Nikolaos Papastavrou, Maria Chatzopoulou, Kyriaki Pegklidou, Ioannis Nicolaou   +3 more
openalex   +1 more source

Synthesis and aldose reductase inhibitory activity of thiazolidinecarboxylic acids containing a disulfide bond.

, 1985
Eishin Kato, Kōji Yamamoto, TOSHIO BABA, Toshio Watanabe, Yoichi Kawashima, Hiroshi Masuda, Masato Horiuchi, MASAYUKI OYA, Tadashi Iso, Jun-ichi Iwao   +9 more
openalex   +2 more sources

Properties of an Aldose Reductase from Pig Lens [PDF]

, 1982
Guy Branlant
openalex   +1 more source