Results 181 to 190 of about 182,045 (267)

Role of Alkannin in the Therapeutic Targeting of Protein-Tyrosine Phosphatase 1B and Aldose Reductase in Type 2 Diabetes: An In Silico and In Vitro Evaluation. [PDF]

ACS Omega
Saeed M, Shoaib A, Tasleem M, Al-Shammary A, Kausar MA, El Asmar Z, Abdelgadir A, Sulieman AME, Ahmed EH, Zahin M, Ansari IA.   +10 more
europepmc   +1 more source

Aldose reductase inhibition and experimental models of pathogenesis in diabetes.

, 1982
Richard Poulsom
openalex   +1 more source

Inhibition of aldose-reductase-2 by a benzofuroxane derivative bf-5m increases the expression of kcne1, kcnq1 in high glucose cultured H9c2 cardiac cells and sudden cardiac death

, 2017
Maria Consiglia Trotta, Monica Salerno, Anna Lisa Brigida, Vincenzo Monda, Antonietta Messina, Carmela Fiore, Roberto Avola, Renato Bernardini, Francesco Sessa, Gabriella Marsala, G Zanghì, Giovanni Messina, Michele D’Amico, Clara Di Filippo   +13 more
openalex   +1 more source

Discovery of Novel Aldose Reductase Inhibitors via the Integration of Ligand-Based and Structure-Based Virtual Screening with Experimental Validation. [PDF]

ACS Omega
Yasir M, Park J, Chun W.
europepmc   +1 more source

Dynamic changes in Beclin-1, LC3B, and p62 in aldose reductase-knockout mice at different time points after ischemic stroke. [PDF]

Heliyon
Li J, Ning Z, Zhong X, Hu D, Wang Y, Cheng X, Deng M.   +6 more
europepmc   +1 more source

GC-MS Profiling of Ethanol-Extracted Polyherbal Compounds from Medicinal Plant (Citrullus colocynthis, Curcuma longa, and Myristica fragrans): In Silico and Analytical Insights into Diabetic Neuropathy Therapy via Targeting the Aldose Reductase. [PDF]

Curr Issues Mol Biol
Kausar MA, Anwar S, Elagib HM, Parveen K, Hussain MA, Najm MZ, Nair A, Kar S.   +7 more
europepmc   +1 more source

Tempol, a Superoxide Dismutase Mimetic, Inhibits Wallerian Degeneration Following Spinal Cord Injury by Preventing Glutathione Depletion and Aldose Reductase Activation. [PDF]

J Neurotrauma
Zeman RJ, Brown AM, Wen X, Ouyang N, Etlinger JD.   +4 more
europepmc   +1 more source

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The role of aldose reductase in polyol pathway: An emerging pharmacological target in diabetic complications and associated morbidities.

Current Pharmaceutical Biotechnology, 2023
The expression of aldose reductase leads to a variety of biological and pathological effects. It is a multifunctional enzyme which has a tendency to reduce aldehydes to the corresponding sugar alcohol.
J. Gupta
semanticscholar   +1 more source

Aldose Reductase Inhibitors

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1990
The present management of diabetes consists of attempting to control blood sugar tightly in the normal range and to treat individual complications such as neuropathy and retinopathy as they appear. Whereas these measures are perhaps effective in slowing the progress of diabetic complications, they do not cure the underlying process.
W R, Kirchain, M S, Rendell
openaire   +2 more sources