Results 11 to 20 of about 182,045 (267)

Aldose Reductase [PDF]

Definitions, 2020
D. A. Thayer
semanticscholar   +3 more sources

Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations

Journal of Chemistry, 2015
Aldose reductase (ALR2), a vital enzyme involved in polyol pathway, has befitted as a novel drug target in antidiabetes drug discovery process. In the present study, the binding mode and pharmacokinetic properties of potential polyphenolic compounds with
Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Sugunadevi Sakkiah, Byoung Ryong Jeong   +4 more
doaj   +2 more sources

Structure-Guided Identification and Evaluation of Epalrestat and Ranirestat-Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy. [PDF]

ChemistryOpen
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Khan MS, Yadav DK, Shahwan M, Shamsi A.
europepmc   +2 more sources

Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches

Biology, 2022
The inhibition of aldose reductase is considered as a strategy to counteract the onset of both diabetic complications, upon the block of glucose conversion in the polyol pathway, and inflammation, upon the block of 3-glutathionyl-4-hydroxynonenal ...
Francesco Balestri, Giulio Poli, Lucia Piazza, Mario Cappiello, Roberta Moschini, Giovanni Signore, Tiziano Tuccinardi, Umberto Mura, Antonella Del Corso   +8 more
doaj   +1 more source

Potensi Senyawa Aktif Ekstrak Kayu Manis Padang (Cinnamomum burmanii) sebagai Inhibitor Enzim Aldose Reductase secara Moleculer Docking

JRST: Jurnal Riset Sains dan Teknologi, 2022
Neuropati diabetes merupakan salah satu komplikasi yang diakui berhubungan dengan meningkatnya stres oksidatif. Penyebab stres oksidatif dapat dicegah dengan menghambat enzim aldose reductase.
Nawfal Imanudin, Muhammad Fakih Kurniawan, Titi Rohmayanti   +2 more
doaj   +1 more source

Computational screening identifies selective aldose reductase inhibitors with strong efficacy and limited off target interactions. [PDF]

Sci Rep
Rojas JJ, Pestana-Nobles R, Pacheco-Londono LC, Utria-Munive J, Galan-Freyle NJ.   +4 more
europepmc   +3 more sources

Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations

Molecules, 2022
For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple stages inhibitory assays were used to explore the antidiabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed).
Tejaswini Maradesha, Shashank M. Patil, K. Al-Mutairi, R. Ramu, SabbaRao V. Madhunapantula, Taha Alqadi   +5 more
semanticscholar   +1 more source

Aldose Reductase Inhibitors [PDF]

Journal of Enzyme Inhibition, 2001
Aldose reductase ([EC1.1.1.21]: AR) acts on the first step of the polyol metabolic pathway to catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the pathway in individuals with high blood glucose level is closely related to the onset or progression of diabetic complications.
M, Oka, N, Kato
openaire   +2 more sources

Physiological and Pathological Roles of Aldose Reductase

Metabolites, 2021
Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway represents a minor route of glucose metabolism that operates in parallel ...
Mahavir Singh, A. Kapoor, A. Bhatnagar
semanticscholar   +1 more source

Aldose Reductase: An Emerging Target for Development of Interventions for Diabetic Cardiovascular Complications

Frontiers in Endocrinology, 2021
Diabetes is a leading cause of cardiovascular morbidity and mortality. Despite numerous treatments for cardiovascular disease (CVD), for patients with diabetes, these therapies provide less benefit for protection from CVD.
Sravya Jannapureddy, Mira Sharma, Gautham Yepuri, A. Schmidt, R. Ramasamy   +4 more
semanticscholar   +1 more source