Results 191 to 200 of about 182,045 (267)

Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease

Hepatology, 2020
Alcohol‐associated liver disease (ALD) is a common chronic liver disease worldwide with high morbidity and mortality, and no Food and Drug Administration–approved therapies. Fructose (dietary or endogenous), its metabolite uric acid, and aldose reductase
Min Wang, Wei‐Yang Chen, Jingwen Zhang, L. Gobejishvili, S. Barve, C. McClain, S. Joshi‐Barve   +6 more
semanticscholar   +1 more source

Antidiabetic properties of dietary phenolic compounds: Inhibition effects on α‐amylase, aldose reductase, and α‐glycosidase

Biotechnology and applied biochemistry, 2019
Aldose reductase (AR), α‐amylase, and α‐glycosidase are vital enzymes to prevent diabetic complications. Here, AR was purified from sheep kidney using elementary methods with 111.11‐purification fold and with 0.85% purification yield.
Yeliz Demir, Lokman Durmaz, Parham Taslimi, I. Gulcin   +3 more
semanticscholar   +1 more source

Intrinsic Inhibition of Aldose Reductase

Journal of Ocular Pharmacology and Therapeutics, 2001
The development of aldose reductase inhibitors for the treatment of diabetic complications, such as cataract and retinopathy, has been of intense interest in the pharmaceutical community for the last 20 years. To date, aldose reductase inhibitors have been synthetically developed from leads obtained from in vitro screening studies.
P F, Kador, G, Sun, V K, Rait, L, Rodriguez, Y, Ma, K, Sugiyama   +5 more
openaire   +2 more sources

The Aldose Reductase Controversy

Diabetes, 1994
ext to the debate as to whether chronic hyperglycemia is the primary cause of the late vascular complications of diabetes, the longest running controversy among researchers and clinicians studying this disease is the role of the sorbitol pathway, particularly its initial enzymatic step, the reduction of glucose to sorbitol by aldose reductase in the ...
openaire   +2 more sources

Spiro Hydantoin Aldose Reductase Inhibitors

Journal of Medicinal Chemistry, 1988
Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of diabetes mellitus. Spiro hydantoins derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens.
R, Sarges, R C, Schnur, J L, Belletire, M J, Peterson   +3 more
openaire   +2 more sources

The aldose reductase inhibitor site

Metabolism, 1986
Evidence linking the enzyme aldose reductase (alditol:NADP+ oxidoreductase, EC 1.1.1.21) to the pathogenesis of several diabetic complications is rapidly mounting. The results of several animal studies combined with preliminary reports of ongoing clinical trials indicate that inhibition of aldose reductase produces a beneficial effect against such ...
P F, Kador, J H, Kinoshita, N E, Sharpless   +2 more
openaire   +2 more sources

Aldose Reductase Inhibitors: An Update

Annals of Pharmacotherapy, 1993
OBJECTIVE: To update readers on research being conducted with the aldose reductase inhibitor (ARI) tolrestat in treating complications of diabetes mellitus. The article briefly describes early investigations with other ARIs and reviews the more recent studies of tolrestat.
S C, Tsai, T G, Burnakis
openaire   +2 more sources

Immunohistochemical distribution of aldose reductase

The Histochemical Journal, 1982
Aldose reductase (AR) has been purified from canine kidneys, and a monospecific antibody against the enzyme prepared. These antibodies were used in an immunohistochemical test to detect tissue sites of aldose reductase in the dog, a species known to develop diabetic lesions morphologically identical to those seen in diabetic patients. Using this method,
T S, Kern, R L, Engerman
openaire   +2 more sources

Aldose reductase inhibitors: Recent developments

1993
Perfect control of blood glucose levels in diabetic patients might ultimately be achieved with islet or pancreas transplants or with an artificial pancreas. However, to achieve such a goal on a large scale, it will be necessary to overcome the formidable safety or efficacy issues attendant with these approaches (see, e.g., [1, 2]).
R, Sarges, P J, Oates
openaire   +2 more sources

Spiro oxazolidinedione aldose reductase inhibitors

Journal of Medicinal Chemistry, 1982
Spiro oxazolidinediones (2) derived from five- and six-membered ring aralkyl ketones are potent aldose reductase inhibitors in vitro and in vivo. Their novel and general synthesis has been devised with alpha-hydroxyimidates (5) and 4-alkoxy-2-oxo-3-oxazolines (6) as key intermediates, since traditional synthetic routes through alpha-hydroxy amides (8 ...
R C, Schnur, R, Sarges, M J, Peterson
openaire   +2 more sources