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Nitrophenyl Derivatives as Aldose Reductase Inhibitors
Bioorganic & Medicinal Chemistry, 2002Nitrophenyl derivatives were recently discovered as a new class of ALR2 inhibitors by means of docking and database screening of the National Cancer Institute database of organic molecules. The nitro group was predicted to bind to the Tyr48 and His110 active site residues of the enzyme, the site where acidic ALR2 inhibitors such as carboxylic acids ...
COSTANTINO, Luca +3 more
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Aldose reductase inhibitors from natural sources
Natural Product Reports, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Jesús Angel, de la Fuente +1 more
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Aldose reductase inhibitors and cataract
International Ophthalmology, 1991Blindness in diabetics is largely due to retinopathy and/or cataract. Hyperglycaemia and the duration of diabetes are major risk factors for the development of cataract and retinopathy. This review details some of the reactions of glucose that are relevant to the development of complications, and follows the elucidation of monosaccharide autoxidation ...
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Aldose Reductase in Diabetic Microvascular Complications
Current Drug Targets, 2005Most long-term diabetic patients develop microvascular diseases such as retinopathy, nephropathy and neuropathy. Although tight control of blood glucose greatly reduces the incidence of these complications, a significant fraction of diabetic patients with good glycemic control still develop these diseases.
Chung, SSM, Chung, SK
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Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors
Current Eye Research, 1982The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells.
S K, Srivastava +4 more
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Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors
Biochemical Pharmacology, 1990Kinetic patterns of inhibition of homogenous human kidney aldose reductase (AR, EC 1.1.1.21) and aldehyde reductase II (AR II, EC 1.1.1.19) by statil, ICI 105552 [1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-yl acetic acid], tolrestat, alrestatin, chromone carboxylic acid (CCA), quercetin, phenobarbital and sorbinil were studied.
A, Bhatnagar +4 more
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Rat lens aldose reductase: rapid purification and comparison with human placental aldose reductase
Experimental Eye Research, 1983Aldose reductase (alditol:NADP oxidoreductase EC .1.1.1.21), an enzyme in the sorbitol pathway which has been implicated in the pathogenesis of diabetic complications, has been purified from rat lens (RLAR) by affinity chromatography with Amicon Matrex Gel Orange A and its properties have been compared to those of purified human placental aldose ...
R K, Herrmann +2 more
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Inhibition of aldehyde reductase by aldose reductase inhibitors
Biochemical Pharmacology, 1990A broad group of structurally diverse aldose reductase inhibitors including flavonoids, carboxylic acids and hydantoins, have been examined for their ability to inhibit rat kidney aldehyde reductase (EC 1.1.1.19, EC 1.1.1.20) versus rat lens aldose reductase (EC 1.1.1.21).
S, Sato, P F, Kador
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Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Archives of pharmacal research, 2021S. Thakur +4 more
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[Aldose reductase inhibitors].
Journal de pharmacologie, 1987Aldose reductase (AR) is an enzyme which catalyzes the transformation of D-glucose to sorbitol. Under non physiological conditions, like diabetes for example, the accumulation of polyols in the lens, sorbitol in particular, gives a basis to the osmotic hypothesis of cataract formation. AR inhibitors can protect against such accumulation.
P, Dostert, M, Strolin Benedetti
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