Results 21 to 30 of about 182,045 (267)

Computational Assessment of Xanthones from African Medicinal Plants as Aldose Reductase Inhibitors

Computation, 2022
Diabetes mellitus is a life-threatening non-communicable disease that affects all age groups. Despite the increased attention it has received in recent years, the number of diabetic patients has grown exponentially.
Onikepe Deborah Owoseeni, Rajesh B. Patil, Prajakta M. Phage, Ruth Mosunmola Ogboye, Marcus Durojaye Ayoola, Samson Oluwaseyi Famuyiwa, Felix Olusegun Gboyero, Derek Tantoh Ndinteh, Kolade Olatubosun Faloye   +8 more
doaj   +1 more source

Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems

International Journal of Molecular Sciences, 2021
Aldose reductase (AR) is a member of the reduced nicotinamide adenosine dinucleotide phosphate (NADPH)-dependent aldo-keto reductase superfamily. It is also the rate-limiting enzyme of the polyol pathway, catalyzing the conversion of glucose to sorbitol,
N. Niimi, Hideji Yako, Shizuka Takaku, Sookja K. Chung, K. Sango   +4 more
semanticscholar   +1 more source

Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis

Medicinal Chemistry Research, 2021
Sepsis is a life-threatening disease that affects millions of people worldwide. Microbial infections that lead to sepsis syndrome are associated with an increased production of inflammatory molecules.
Antonios Kousaxidis, Lucia Kováčiková, I. Nicolaou, M. Štefek, A. Geronikaki   +4 more
semanticscholar   +1 more source

Modulation of aldose reductase activity by aldose hemiacetals [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior.
BALESTRI, FRANCESCO, CAPPIELLO, MARIO, MOSCHINI, ROBERTA, ROTONDO, ROSSELLA, ABATE, MARCO, DEL CORSO, ANTONELLA, MURA, UMBERTO   +6 more
openaire   +2 more sources

A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

, 2021
In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones (1–8), which were prepared by the solvent-free reaction of 2,4-thiazolidinedione with aromatic aldehydes in the presence of urea, were examined for ...
Belgin Sever, M. Altıntop, Yeliz Demir, Cüneyt Türkeş, Kaan Özbaş, G. Çiftçi, Ş. Beydemir, Ahmet Özdemir   +7 more
semanticscholar   +1 more source

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

BMC Chemistry, 2021
In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for ...
Mohsinul Mulk Bacha, Humaira Nadeem, Sumera Zaib, Sadia Sarwar, Aqeel Imran, Shafiq Ur Rahman, Hafiz Saqib Ali, Muazzam Arif, Jamshed Iqbal   +8 more
doaj   +1 more source

In silico identification of chemical compounds in Spondias mombin targeting aldose reductase and glycogen synthase kinase 3β to abate diabetes mellitus

Informatics in Medicine Unlocked, 2023
Aldose reductase and glycogen synthase kinase 3β (GSK3β) represent two of the ideal drug targets in diabetes due to their role in the pathogenesis of diabetes. Studies have shown that plant compounds provide therapeutics in diabetes management.
B.O. Ajiboye, T.M. Fagbola, I.M. Folorunso, A.W. Salami, O.N. Aletile, B.A. Akomolede, F.I. Ayemoni, K.I. Akinfemiwa, V.O. Anwo, M.I. Ojeleke, B.E. Oyinloye   +10 more
doaj   +1 more source

Synthesis and Activity of a New Series of(Z)-3-Phenyl-2-benzoylpropenoic Acid Derivatives as Aldose Reductase Inhibitors

Molecules, 2007
During the course of studies directed towards the discovery of novel aldose reductase inhibitors for the treatment of diabetic complications, we synthesized a series of new (Z)-3-phenyl-2-benzoylpropenoic acid derivatives and tested their in vitro ...
Shao-Jie Wang, Ju-Fang Yan, Dong Hao, Xin-Wen Niu, Mao-Sheng Cheng   +4 more
doaj   +1 more source

Evaluation of Pharmacokinetic Parameters, Toxicity, and Molecular Docking of Flavonols with Aldose Reductase Enzyme to Find an Effective Compound in Inhibition of this Enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Aldose reductase plays an important role in chronic diabetes and can cause tissue complications. Controlling the activity of aldose reductase provides an important strategy in controlling the complications of diabetes.
Morteza Sadeghi, Mehran Miroliaei
doaj  

Carica papaya Linn. fruit extract inhibited the activities of aldose reductase and sorbitol dehydrogenase: possible mechanism for amelioration of diabetic complications

Future Journal of Pharmaceutical Sciences, 2020
Background Diabetes mellitus is a metabolic disorder which is associated with debilitating complications including eye disease, kidney disorder, and diabetic foot disease.
Mutiu Idowu Kazeem, Ayotomiwa Adeyinka Adeyemi, Abiola Fatimah Adenowo, Mushafau Adewale Akinsanya   +3 more
doaj   +1 more source