Results 31 to 40 of about 182,045 (267)
Brain Communications, 2020 Long-term metabolic aberrations contribute to the development of diabetic neuropathy but the precise mechanism or mechanisms remains elusive. We have previously shown that aldose reductase-deficient mice exhibit delayed onset and progression of ...
H. Mizukami +7 more
semanticscholar +1 more source
INHIBITORY ACTIVITY OF FLAVONOIDS ON THE LENS ALDOSE REDUCTASE OF HEALTHY AND DIABETIC RATS [PDF]
Acta Medica Iranica, 2006 Aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. Inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses.
M. T. Goodarzi +3 more
doaj +1 more source
Bangladesh Journal of Pharmacology, 2012 The primary objective of this study was to investigate the aldose reductase inhibitory activity of flavonoids using in silico docking studies. In this perspective, flavonoids like biochanin, butein, esculatin, fisetin and herbacetin were selected ...
Arumugam Madeswaran +5 more
doaj +1 more source
Aldo keto reductases 1B in endocrinology and metabolism
Frontiers in Pharmacology, 2012 The aldose reductase (human AKR1B1/mouse Akr1b3) has been the focus of many research because of its role in diabetic complications. The starting point of these alterations is the massive entry of glucose in polyol pathway where it is converted into ...
Emilie ePastel +4 more
doaj +1 more source
Tạp chí Khoa học và Công nghệAldose reductase is a crucial component of the polyol pathway and catalyzes the NADPH-dependent reduction of glucose to sorbitol. The high activity of Aldose reductase is involved in the development and pathophysiology of diabetes complications ...
Thanh Hoa Tran +3 more
doaj +1 more source
Plants, 2022 Aristotelia chilensis is a plant whose fruit is considered a powerful natural antioxidant. During the last years, some investigations of the fruit have been carried out, finding antioxidant properties in the juice or the phenolic fraction.
Adriana Pineda +3 more
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Journal of Biological Chemistry, 2019 Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic
L. Sánchez-Lozada +8 more
semanticscholar +1 more source
Disease Models & Mechanisms, 2019 Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG.
Sangeetha Iyer +10 more
semanticscholar +1 more source
Teknologi Pangan: Media Informasi dan Komunikasi Ilmiah Teknologi PertanianSynsepalum dulcificum leaves are known to contain bioactive compounds, especially flavonoids, which have important biological activities, including inhibition of aldose reductase, an enzyme involved in diabetes complications.
Wike Adhi Anggono +2 more
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Osmolyte regulation by TonEBP/NFAT5 during anoxia-recovery and dehydration–rehydration stresses in the freeze-tolerant wood frog (Rana sylvatica) [PDF]
PeerJ, 2017 Background The wood frog, Rana sylvatica, tolerates freezing as a means of winter survival. Freezing is considered to be an ischemic/anoxic event in which oxygen delivery is significantly impaired. In addition, cellular dehydration occurs during freezing
Rasha Al-attar +2 more
doaj +2 more sources