Results 41 to 50 of about 182,045 (267)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Araucaria heterophylla oleogum resin essential oil is a novel aldose reductase and butyryl choline esterase enzymes inhibitor: in vitro and in silico evidence

Scientific Reports, 2023
The essential oil isolated by hydrodistillation of the oleogum resin of Araucaria heterophylla has been analyzed by GC–MS. Twenty-four components accounting to 99.89% of the total detected constituents of this essential oil were identified.
Amal F. Soliman, Mohamed A. Sabry, Gehad Abdelwahab   +2 more
doaj   +1 more source

Phytosulfokine signalling blocks mycotoxin toxicity in Arabidopsis and mediates suppression of cell death activated by bacterial microbe‐associated molecular patterns

New Phytologist, EarlyView.
Summary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Ali O. Alqarni, John M. U. Hamilton, Adrian P. Brown, Stephen Chivasa   +3 more
wiley   +1 more source

Citrus aurantifolia (Christm.) Swingle (lime) Fruit Extract Inhibits the Activities of Polyol Pathway Enzymes

eFood, 2020
Diabetes mellitus is associated with several complications, which may result from one or more factors including increased flux of polyol pathway. This study evaluated the inhibitory potential of four citrus fruits namely Citrus paradisi Macfad.
Mutiu Idowu Kazeem, Habeeb Adebodun Bankole, Tolulope Israel Oladokun, Ahmed Oloruntoba Bello, Monsurah Adenike Maliki   +4 more
doaj   +1 more source

Simulasi Docking Senyawa Aktif Daun Binahong Sebagai Inhibitor Enzyme Aldose Reductase

Sel Jurnal Penelitian Kesehatan, 2019
The metabolic syndrome is the cause of death around the world caused by diabetic mellitus. Binahong leaf is a kind of plant that is widely used to treat various diseases.
Andrio Suhadi, Rizarullah Rizarullah*, Feriyani Feriyani   +2 more
semanticscholar   +1 more source

Electrophysiological diagnosis using the coefficient of variation of R‐R intervals and a point‐of‐care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 280-290, February 2026.
ABSTRACT Aims/Introduction While treatment for diabetic polyneuropathy (DPN) is still developing, progress has stagnated. The alignment between pathological neurodegeneration in DPN and patients' subjective symptoms is often low, yet these symptoms are frequently used for diagnosis.
Tatsuhito Himeno, Hideki Kamiya, Yuka Shibata, Masato Kase, Hiromi Nakai‐Shimoda, Dai Yamagami, Masahiro Saito, Teruo Jojima, Aiko Arimura, Kenta Murotani, Chieko Suzuki, Hiroki Mizukami, Takahisa Deguchi, Yoshimasa Aso, Jiro Nakamura   +14 more
wiley   +1 more source

Docking studies: In silico aldose reductase inhibitory activity of commercially available flavonoids

Bangladesh Journal of Pharmacology, 2012
New drugs for the inhibition of the enzyme aldose reductase are in development and they have to be screened before being considered for preclinical and clinical evaluation.
Muthuswamy Umamaheswari, C. S. Aji, Kuppuswamy Asokkumar, Thirumalaisamy Sivsshanmugam, Varadharajan Subhadradevi, Puliyath Jagannath, Arumugam Madeswaran   +6 more
doaj   +1 more source

Development of novel oxotriazinoindole inhibitors of aldose reductase: isosteric sulfur/oxygen replacement in the thioxotriazinoindole cemtirestat markedly improved inhibition selectivity.

Journal of Medicinal Chemistry, 2019
Inhibition of aldose reductase (AR), the first enzyme of the polyol pathway, is a promising approach in treatment of diabetic complications. We proceeded with optimization of the thioxotriazinoindole scaffold of the novel aldose reductase inhibitor ...
M. Hlaváč, Lucia Kováčiková, M. Prnova, Peter Šramel, G. Addová, M. Májeková, Gilles Hanquet, A. Boháč, M. Štefek   +8 more
semanticscholar   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 310-320, February 2026.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica (M. indica) and Mucuna urens (M. urens) seeds extracts against some key enzymes (α-amylase, α-glucosidase and aldose reductase) implicated in the
Emmanuel Anyachukwu Irondi, Ganiyu Oboh, Afolabi Akintunde Akindahunsi, Aline Augusti Boligon, Margareth Linde Athayde   +4 more
doaj   +1 more source