Results 51 to 60 of about 182,045 (267)

Electrochemical Biosensing of Glucose Based on the Enzymatic Reduction of Glucose

Sensors, 2022
In this work, the enzyme aldehyde reductase, also known as aldose reductase, was synthesized and cloned from a human gene. Spectrophotometric measurements show that in presence of the nicotinamide adenine dinucleotide phosphate cofactor (NADPH), the ...
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda   +8 more
doaj   +1 more source

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu, Jingsheng Yuan, Shitong Su, Jiaqi Han, Ni Zeng, Yuhan Ma, Nianyong Chen, Tao Lv   +7 more
wiley   +1 more source

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds

PLoS ONE, 2018
Diabetes mellitus is a chronic disease that is becoming a serious global health problem. Diabetes has been considered to be one of the major risks of cataract and retinopathy. Synthetic and natural product inhibitors of carbohydrate degrading enzymes are
Diganta Kalita, David G. Holm, Daniel V. LaBarbera, J. Petrash, S. Jayanty   +4 more
semanticscholar   +1 more source

Recent Advances in the Bioactive Compounds of Prunes (Prunus domestica L.) and Their Health Benefits

Food Frontiers, Volume 7, Issue 1, January 2026.
Prunes (Prunus domestica L.) are a functional food rich in diverse bioactive compounds, including polyphenols (such as chlorogenic acid and anthocyanins), polysaccharides, and sorbitol.This review comprehensively synthesizes current research on the nutritional composition and biological activities of prunes, highlighting their multifaceted health ...
Luyang Han, Tiantian Fu, Menglin Zhou, Manxi Wu, Han Yang, Jinping Cao, Jinhu Tian, Chongde Sun, Yaqun Liu, Feifei Gao, Yue Wang   +10 more
wiley   +1 more source

Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein molecules. Methods: The phytoconstituents of Ficus benghalensis were queried for inhibitors of alpha-glucosidase, also ...
Pukar Khanal, B M Patil
doaj   +1 more source

Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird

Molecular Ecology, Volume 35, Issue 2, January 2026.
ABSTRACT Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early‐life developmental stress. Japanese quail Coturnix japonica) males produce a unique seminal foam that enhances fertilisation success.
Chloe Mason, Martin Garlovsky, Oscar Vedder, Trong Khoa Pham, Rachel George, Barbara Tschirren, Nicola Hemmings   +6 more
wiley   +1 more source

Seminal Extracellular Vesicles LGALS3BP as a Potential Biomarker of Varicocele‐Associated Infertility in TMT‐Based Quantitative Proteomic Analysis

Andrologia, Volume 2026, Issue 1, 2026.
The proteomic analysis of seminal plasma (SP) is a powerful tool for screening and identifying potential novel biomarkers of male infertility. However, the proteomic composition of seminal extracellular (SE) vesicles in varicocele (VC) is still poorly characterized.
Cheng Yang, Jian-xiong Li, Xian-yuan Lv, Ran-ran Zhou, Jun-hao Zhou, Cun-dong Liu, Shan-chao Zhao, Debarshi Sarkar   +7 more
wiley   +1 more source

α-Amylase, α-glucosidase and aldose reductase inhibitory and molecular docking studies on Tinospora cordifolia (Guduchi) leaf extract

Future Journal of Pharmaceutical Sciences
Background Type II diabetes mellitus is posing a severe health threat throughout the globe due to its associated pathophysiological risks and high mortality rate.
Hemlata Janardhan Bhosale, Shailesh Vaijeenath Mamdapure, Ramdas Balaji Panchal, Umesh Pravin Dhuldhaj   +3 more
doaj   +1 more source

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Scientific Reports, 2017
Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy.
H. Sonowal, P. Pal, Jian-jun Wen, S. Awasthi, K. Ramana, S. Srivastava   +5 more
semanticscholar   +1 more source

Qinggan Mingshi Granules Inhibited Ferroptosis to Treat Diabetic Retinopathy in Mice Through NRF2/GPX4 Axis

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Diabetic retinopathy (DR) is a common microvascular complication of diabetes, which seriously affected the life quality in diabetic patients. Developing novel therapy to improve DR is essential. Qinggan Mingshi granules (QGMS) have been demonstrated with protective effects on DR clinically.
Zhongyong Zhang, Qianqian Jin, Hongmin Zhao, Yingkai Liu, Meng Wang, Zhongqian Han, Jin Wu, Shuquan Lv, Xiaoyun Wang, Wei Chen, Qingjin Wang, Hailong Bai, Yuansong Wang, Weibo Wen   +13 more
wiley   +1 more source