Results 61 to 70 of about 182,045 (267)

Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Maturation in Aged Mice: A Multitarget Mechanistic Study Using Network Pharmacology and Molecular Simulations

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Mitochondrial dysfunction plays a critical role in ovarian aging and the associated decline in female fertility. Nicotinamide riboside (NR), a vitamin B3 derivative and dietary NAD+ precursor, has shown antiaging potential, yet its molecular mechanisms in ovarian function are not fully understood.
Ningyu Sun, Xiang Cheng, Lu Lu, Wuwen Zhang, Kai Li, Yuanyuan Chen, Yun Li, Chunling Liu, Qinhua Zhang, Ping Yin, Anupama Bose   +10 more
wiley   +1 more source

Role of aldose reductase C-106T polymorphism among diabetic Egyptian patients with different microvascular complications

American Journal of Experimental and Clinical Research, 2014
The aldose reductase pathway proves that elevated blood glucose promotes cellular dysfunction. The polyol pathway converts excess intracellular glucose into alcohols via activity of the aldose reductase. This enzyme catalyzes the conversion of glucose to
Nermine Hossam Zakaria, Salah Ahmed Marzouk, Abla Ahmed Abou Zeid, Eman Saeed Gharaff   +3 more
doaj   +2 more sources

Polyphenols of marine red macroalga Symphyocladia latiuscula ameliorate diabetic peripheral neuropathy in experimental animals

Heliyon, 2019
Aims: Chronic hyperglycaemia activates the polyol pathway of glucose metabolism thereby stimulating the activation aldose reductase enzyme that in turn initiates a cascade of deleterious events, eventually, leading to nerve damage or neuropathy.
Suman Samaddar, Raju Koneri
doaj   +1 more source

Biochemical Analysis and Human Aldose Reductase Inhibition Activity of Selected Medicinal Plants of Nepal

Journal of Chemistry, 2023
Aldose reductase has received extensive research as a key enzyme in the development of long-term problems linked to diabetes mellitus. Overexpression of this enzyme or with exceeded glucose concentration in the blood increases sorbitol on the retina ...
Siddha Raj Upadhyaya, Lila Bahadur Magar, Ranjita Thapa, Soniya Joshi, Karan Khadayat, Bishnu P. Marasini, Niranjan Parajuli   +6 more
doaj   +1 more source

Aldose and Aldehyde Reductase Exhibit Isocorticosteroid Reductase Activity [PDF]

European Journal of Biochemistry, 1983
In this paper we describe the reduction of corticosteroid metabolites containing the 17 beta-aldol side chain (isocorticosteroids) by aldose and aldehyde reductase from human tissues. Aldose reductase catalyzed the reduction of the aldehydes derived from cortisol and corticosterone at about the same rate, whereas aldehyde reductase preferentially acted
B, Wermuth, C, Monder
openaire   +2 more sources

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, Volume 72, Issue 6, Page 1752-1762, December 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Aldose reductase mediates retinal microglia activation [PDF]

Biochemical and Biophysical Research Communications, 2016
Retinal microglia (RMG) are one of the major immune cells in charge of surveillance of inflammatory responses in the eye. In the absence of an inflammatory stimulus, RMG reside predominately in the ganglion layer and inner or outer plexiform layers.
Kun-Che Chang, Biehuoy Shieh, J. Mark Petrash   +2 more
openaire   +2 more sources

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

Phytochemical profiling and in silico evaluation of Brassica oleracea stem bioactives as novel aldose reductase inhibitors for diabetic neuropathy treatment

Journal of Applied Pharmaceutical Research
Background: Diabetic neuropathy affects over 50% of diabetic patients, causing significant morbidity and economic burden exceeding $327 billion annually. Current treatments offer limited relief, accompanied by considerable side effects.
Rajashree Dadasaheb Ghogare, Rahul Rajendra Kunkulol, Deepak Babasaheb Nehe   +2 more
doaj   +1 more source

Aldosereductase: structure, mechanism of action, biological role and functioning according to normo and hyperglycemia

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2020
The review summarizes the literature on the structure, biological role and mechanism of action of aldose reductase at different blood glucose levels. Aldosereductase is the first enzyme of the sorbitol (polyol) pathway to glucose metabolism.
Y. M. Makukh, T. M. Gryvul, A. Ya. Krasnevich, D. S. Vignan   +3 more
doaj   +1 more source