Results 71 to 80 of about 182,045 (267)

Natural aldose reductase inhibitors for treatment and prevention of diabetic cataract: A review

Herba Polonica, 2022
Introduction: Aldose reductase (AR) is an enzyme that catalyzes the reduction of glucose to sorbitol responsible for the development of diabetic complications like cataracts. Medicinal plants contain several phytocompounds that can inhibit this enzyme.
Daoudi Nour Elhouda, Bouziane Omar, Bouhrim Mohamed, Bnouham Mohamed   +3 more
doaj   +1 more source

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Integrated network pharmacology, molecular docking, and dynamics simulations revealed the anti‐osteoarthritis mechanism of Ermiao San. Key bioactive compounds (e.g., quercetin) synergistically target core proteins (e.g., TNF and IL‐6), modulating critical pathways (e.g., TNF signaling) to inhibit inflammation and cartilage degradation, demonstrating a ...
Zhenyu Song, Jincheng Huang, He Zhu, Xu Li, Qianqian Cao, Liyang Yang, Meng Zhang, Hongkai Wang, Haoyue Sun   +8 more
wiley   +1 more source

Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
Sulfated polysaccharides from red seaweed improved testicular FSH and insulin signaling, which upregulated GLUT4 level and improved glycolysis and energy metabolism in testes of diabetic rats. ABSTRACT Testicular glucose homeostasis plays important roles in testicular energy metabolism and male fertility, but it is altered in type 2 diabetes (T2D ...
Ochuko L. Erukainure, Tosin A. Olasehinde, Olanrewaju S. Olayeriju, Bukola Omotoso, Md. Shahidul Islam, Ademola O. Olaniran   +5 more
wiley   +1 more source

Soyasaponins from Zolfino bean as aldose reductase differential inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1).
Francesco Balestri, Marinella De Leo, Carlo Sorce, Mario Cappiello, Luca Quattrini, Roberta Moschini, Carlotta Pineschi, Alessandra Braca, Concettina La Motta, Federico Da Settimo, Antonella Del-Corso, Umberto Mura   +11 more
doaj   +1 more source

Blanching influences the phenolics composition, antioxidant activity, and inhibitory effect of Adansonia digitata leaves extract on α‐amylase, α‐glucosidase, and aldose reductase

Food Science & Nutrition, 2016
Adansonia digitata (A. digitata) leaves serve as food and has several medicinal uses in many parts of the world. This study evaluated the influence of blanching on the phenolics composition, antioxidant activity, and inhibitory effect of methanol extract
E. A. Irondi, J. Akintunde, S. Agboola, A. Boligon, M. Athayde   +4 more
semanticscholar   +1 more source

1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline

Aging Cell, Volume 24, Issue 12, December 2025.
Noninvasive 1275‐nm photobiomodulation improves brain drainage and promotes lymphatic clearance of advanced glycation end products (AGEs) in an aging model (AM) in male mice. These effects are associated with nitric oxide release‐mediated dilation of meningeal lymphatic vessels (MLVs).
Hao Lin, Shaojun Liu, Qihang Yang, Junming Li, Jue Wang, Oxana Semyachkina‐Glushkovskaya, Dongyu Li, Tingting Yu, Dan Zhu   +8 more
wiley   +1 more source

The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena.
Livia Misuri, Mario Cappiello, Francesco Balestri, Roberta Moschini, Vito Barracco, Umberto Mura, Antonella Del-Corso   +6 more
doaj   +1 more source

Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies.
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti   +10 more
doaj   +1 more source

Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats

Biomolecules & Therapeutics, 2016
Naturally occurring coumarin compounds have received substantial attention due to their pharmaceutical effects. Esculetin is a coumarin derivative and a polyphenol compound that is used in a variety of therapeutic and pharmacological strategies. However,
Chan-Sik Kim, Junghyun Kim, Y. Lee, E. Sohn, Jin Sook Kim   +4 more
semanticscholar   +1 more source

miR‐27a‐3p Upregulation and Netrin‐1 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes

European Journal of Neurology, Volume 32, Issue 12, December 2025.
ABSTRACT Background Inflammation is increasingly recognized in the pathogenesis of diabetic neuropathy (DN). Circulating miR‐27a‐3p levels are closely related to inflammation and increased in patients with diabetic nephropathy and retinopathy. miR‐27a‐3p has a predicted binding site in the 3 UTR of Netrin‐1 mRNA, an anti‐inflammatory nerve growth ...
Asif Mondal, Sucharita Banerjee, Somnath Naskar, Chiranjit Bose, Chinmay Saha, Subhasish Pramanik, Bidisha Mukherjee, Piyali Jati, Pranab Kumar Sahana, Rayaz A. Malik, Satinath Mukhopadhyay   +10 more
wiley   +1 more source