Results 81 to 90 of about 182,045 (267)

Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM‐1 Upregulation

Experimental Dermatology, Volume 34, Issue 12, December 2025.
ABSTRACT Alopecia areata (AA) is an inflammatory hair loss disorder caused by an immune‐mediated attack of the hair follicle (HF) bulb. Active disease is characterised by a peribulbar proinflammatory infiltrate, HF immune privilege collapse and premature catagen induction, yet the underlying drivers of AA remain poorly understood.
Madoc Dawson, Derek Pye, Rebecca Mahon, George Taylor, Asim Shahmalak, Bessam Farjo, Nilofer Farjo, Matthew Harries, Talveen S. Purba   +8 more
wiley   +1 more source

Hyperglycemia Impairs Acetylcholine-Induced Vasodilation of Retinal Arterioles Through Polyol Pathway–Independent Mechanisms in Rats

Journal of Pharmacological Sciences, 2010
We previously reported that acetylcholine (ACh)–induced vasodilation of retinal arterioles is diminished in diabetic rats; however, the underlying mechanism(s) of this phenomenon has not been fully elucidated.
Asami Mori, Orie Saigo, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii   +4 more
doaj   +1 more source

A Review of Antioxidant Activity, Anti‐Inflammatory Properties, Apoptosis‐Regulatory Effects, and Immune System Modulation of Juglans regia L. (Walnut)

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
J. regia L. represents a valuable natural source of antioxidants, anti‐inflammatory agents, apoptosis‐regulatory agents, and immunomodulators. The walnut‐rich phytochemical profile contributes to its therapeutic potential in combating oxidative stress and inflammation, regulating apoptosis and immune responses.
Mahboobeh Ghasemzadeh Rahbardar, Mostafa Rashki, Mohammad Hossein Boskabady   +2 more
wiley   +1 more source

Inhibitory Effects of Colocasia esculenta (L.) Schott Constituents on Aldose Reductase

Molecules, 2014
The goal of this study was to determine the rat lens aldose reductase-inhibitory effects of 95% ethanol extracts from the leaves of C. esculenta and, its organic solvent soluble fractions, including the dichloromethane (CH2Cl2), ethyl acetate (EtOAc), n-
Hong Mei Li, Seung Hwan Hwang, Beom Goo Kang, Jae Seung Hong, Soon Sung Lim   +4 more
doaj   +1 more source

Protective Effect of Rutaecarpine in Streptozotocin-Induced Diabetes Cataracts Through the Inhibition of Aldose Reductase Activity in Male Albino Rats [PDF]

, 2023
Zhaoli Chen, Xiaoyu Zhang, Ning Liu, Ting Zhang   +3 more
openalex   +1 more source

Aldose Reductase Inhibition, Molecular Docking, and Density Functional Theory Studies of Dinaphthodiospyrol H from Diospyros kaki (Japanese Persimmon)

Journal of Pure and Applied Microbiology
This study explores the aldose reductase (AR) inhibitory potential of dinaphthodiospyrol H, a compound isolated from Diospyros kaki (Japanese persimmon).
Abdur Rauf, Saima Naz, Zubair Ahmad, Umer Rashid, Marryum, Khurshid Ayub, Muhammad Aetizaz, Ho Soonmin, Naveed Muhammad, Mujeeb-ur-Rehman, Walaa F. Alsanie, Abdulhakeem S. Alamri   +11 more
doaj   +1 more source

Transcription Factor Nrf2 Regulates Promoter Activity of Mouse Aldose Reductase (AKR1B3) Gene

Journal of Pharmacological Sciences, 2005
Transcription factor Nrf2 regulates gene expression of drug metabolizing enzymes such as glutathione S-transferase via the antioxidant response element, ARE.
Toru Nishinaka, Chihiro Yabe-Nishimura
doaj   +1 more source

ANTI-DIABETIC AND ALDOSE REDUCTASE INHIBITORY POTENTIAL OF PSIDIUM GUAJAVA BY IN VITRO ANALYSIS

, 2016
Objective: The objective of the present study was to determine the cellular level effect on glucose uptake and aldose reductase inhibitory activity of different extracts of traditional medicinal plant Psidium guajava .
S. Anand, M. Arasakumari, P. Prabu, A. Amalraj   +3 more
semanticscholar   +1 more source

A pilot open-label study of aldose reductase inhibition with AT-001 (caficrestat) in patients hospitalized for COVID-19 infection: Results from a registry-based matched-control analysis

, 2021
Juan Gaztañaga, Ravichandran Ramasamy, Ann Marie Schmidt, Glenn I. Fishman, Shoshana Schendelman, Karthinathan Thangavelu, Riccardo Perfetti, Stuart D. Katz   +7 more
openalex   +2 more sources

Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity

Acta Pharmacologica Sinica, 2021
Jiahui He, Q. Hong, Binjia Chen, Shaoyuan Cui, Ran Liu, G. Cai, Jiao Guo, Xiang-Mei Chen   +7 more
semanticscholar   +1 more source