Results 1 to 10 of about 14,544 (270)

Aldose reductase inhibitor form Cassia glauca: A comparative study of cytotoxic activity with Ag nanoparticles (NPs) and molecular docking evaluation. [PDF]

PLoS ONE, 2020
UPLC-MS/MS profiling of Cassia glauca leaves extract revealed the identification of 10 flavonoids. Kaempferol 3-O-β-D-rutinoside was isolated and studied for its cytotoxic activity. It showed high cytotoxic effects against MCF-7 (IC50 of 4.6±0.038 μg/ml)
Samir M Osman, Nahla A Ayoub, Safaa A Hafez, Haitham A Ibrahim, Mohamed A El Raey, Soad Z El-Emam, Ahmed A Seada, Amr M Saadeldeen   +7 more
doaj   +2 more sources

Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats [PDF]

Journal of Diabetes Research, 2017
Objective. To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. Methods.
Lixia Ji, Lixia Cheng, Zhihong Yang
doaj   +2 more sources

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins [PDF]

Journal of Diabetes Research, 2017
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses.
Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K. Srivastava, Kota V. Ramana   +4 more
doaj   +2 more sources

Ameliorating effect of the aldose reductase inhibitor 1-Acetyl-5-phenyl-1 H-pyrrol-3-ylacetate on galactose-induced cataract [PDF]

Scientific Reports
Diabetes mellitus, as a common chronic disease, easily leads to significant changes in the structure of the eye, among which diabetic cataract is particularly common.
Xi Wang, Zhuoya Li, Ying Xing, Yaru Wang, Shiyao Wang, Liping Wang, Hui Zhang   +6 more
doaj   +2 more sources

Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling [PDF]

Pharmaceuticals
Background/Objectives: Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetic agents that regulate blood glucose by preventing the degradation of active incretin hormones.
Raquel N. S. Roriz, Claudia J. P. Cardozo, Gabriela A. Freire, Caio B. R. Martins, Raimundo Rigoberto B. X. Filho, Landerson Lopes Pereira, Gisele F. P. Rangel, Tiago L. Sampaio, Lyanna R. Ribeiro, Gisele Silvestre Silva, Isabelle Maia, Deysi Viviana Tenazoa Wong, Daniele O. B. Sousa, Ariclécio Cunha de Oliveira, Eduardo Reina, Lidia Moreira Lima, Walter Peláez, Matheus Nunes da Rocha, Márcia Machado Marinho, Hélcio Silva dos Santos, Emmanuel Silva Marinho, Jane Eire Silva Alencar de Menezes, Fátima Regina Mena Barreto Silva, Kirley Marques Canuto, Nylane M. N. Alencar, Marisa Jadna Silva Frederico   +25 more
doaj   +2 more sources

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity [PDF]

Scientific Reports, 2017
Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy.
Himangshu Sonowal, Pabitra B. Pal, Jian-Jun Wen, Sanjay Awasthi, Kota V. Ramana, Satish K. Srivastava   +5 more
doaj   +2 more sources

Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications [PDF]

Frontiers in Bioinformatics
BackgroundDiabetes remains a leading cause of morbidity and mortality due to various complications induced by hyperglycemia. Inhibiting Aldose Reductase (AR), an enzyme that converts glucose to sorbitol, has been studied to prevent long-term diabetic ...
Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe   +10 more
doaj   +2 more sources

(−)-Kusunokinin as a Potential Aldose Reductase Inhibitor: Equivalency Observed via AKR1B1 Dynamics Simulation [PDF]

ACS Omega, 2020
Tanotnon Tanawattanasuntorn, Tienthong Thongpanchang, Thanyada Rungrotmongkol, Chonnikan Hanpaibool, Potchanapond Graidist, Varomyalin Tipmanee   +5 more
doaj   +2 more sources

Potensi Senyawa Aktif Ekstrak Kayu Manis Padang (Cinnamomum burmanii) sebagai Inhibitor Enzim Aldose Reductase secara Moleculer Docking

JRST: Jurnal Riset Sains dan Teknologi, 2022
Neuropati diabetes merupakan salah satu komplikasi yang diakui berhubungan dengan meningkatnya stres oksidatif. Penyebab stres oksidatif dapat dicegah dengan menghambat enzim aldose reductase.
Nawfal Imanudin, Muhammad Fakih Kurniawan, Titi Rohmayanti   +2 more
doaj   +1 more source

Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches

Biology, 2022
The inhibition of aldose reductase is considered as a strategy to counteract the onset of both diabetic complications, upon the block of glucose conversion in the polyol pathway, and inflammation, upon the block of 3-glutathionyl-4-hydroxynonenal ...
Francesco Balestri, Giulio Poli, Lucia Piazza, Mario Cappiello, Roberta Moschini, Giovanni Signore, Tiziano Tuccinardi, Umberto Mura, Antonella Del Corso   +8 more
doaj   +1 more source