Results 91 to 100 of about 14,544 (270)

Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase

Journal of Translational Medicine, 2023
Background Nonalcoholic steatohepatitis (NASH) is a progressive and inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) characterized by hepatocellular injury, inflammation, and fibrosis in various stages. More than 20% of patients with NASH
Wei Shi, Guang Xu, Yuan Gao, Jun Zhao, Tingting Liu, Jia Zhao, Huijie Yang, Ziying Wei, Hui Li, An-Long Xu, Zhaofang Bai, Xiaohe Xiao   +11 more
doaj   +1 more source

Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
Sulfated polysaccharides from red seaweed improved testicular FSH and insulin signaling, which upregulated GLUT4 level and improved glycolysis and energy metabolism in testes of diabetic rats. ABSTRACT Testicular glucose homeostasis plays important roles in testicular energy metabolism and male fertility, but it is altered in type 2 diabetes (T2D ...
Ochuko L. Erukainure, Tosin A. Olasehinde, Olanrewaju S. Olayeriju, Bukola Omotoso, Md. Shahidul Islam, Ademola O. Olaniran   +5 more
wiley   +1 more source

Flavonoids and its derivatives from Callistephus chinensis flowers and their inhibitory activities against alpha-glucosidase [PDF]

, 2013
Inhibitors of carbohydrate-hydrolysing enzymes play an important role for the treatment of diabetes. One of the therapeutic methods for decreasing of postprandial hyperglycemia is to retard absorption of glucose by the inhibition of carbohydrate ...
Bi, Xiuli, Li, Wei, Liu, Jingxin, Liu, Zhenting, Zhang, Xiaoshu, Zhao, Yuqing   +5 more
core  

Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Deliang Cao, Dixian Luo, Gebo Wen, Jianghua Liu, Jing Zhong, Jingjing Tan, Qinghai Zhang, Renxian Cao, Xuyu Zu, Ying Wu   +9 more
core   +2 more sources

Lens Aldose Reductase Inhibitory and Free Radical Scavenging Activity of Fractions of <i>Chromolaena odorata</i> (Siam Weed): Potential for Cataract Remediation

Notulae Scientia Biologicae, 2016
Searching for effective and safe aldose reductase (AR) inhibitor agent is a major thrust area in the mainstream of anti-cataractogenic research. This study was set up to investigate the in vitro aldose reductase inhibitory (ARI) activity of fractions of ...
Emmanuel O. AJANI, Saheed SABIU, Fisayo A. BAMISYAE, Nurain O. ISMAILA, Olayinka S. ABDULSALAM   +4 more
doaj   +1 more source

1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline

Aging Cell, Volume 24, Issue 12, December 2025.
Noninvasive 1275‐nm photobiomodulation improves brain drainage and promotes lymphatic clearance of advanced glycation end products (AGEs) in an aging model (AM) in male mice. These effects are associated with nitric oxide release‐mediated dilation of meningeal lymphatic vessels (MLVs).
Hao Lin, Shaojun Liu, Qihang Yang, Junming Li, Jue Wang, Oxana Semyachkina‐Glushkovskaya, Dongyu Li, Tingting Yu, Dan Zhu   +8 more
wiley   +1 more source

Long-Term Treatment With Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Suppresses Diabetic Neuropathy and Cataract Formation in Rats

Journal of Pharmacological Sciences, 2008
We investigated the chronic functional and histopathological changes in the sciatic nerve and lens of streptozotocin (STZ)-diabetic rats and evaluated the preventive effects of ranirestat (AS-3201), a potent aldose reductase inhibitor, on these changes ...
Takafumi Matsumoto, Yoshiyuki Ono, Akemi Kuromiya, Kaoru Toyosawa, Yoshinaka Ueda, Vera Bril   +5 more
doaj   +1 more source

Isatin Derivatives as a New Class of Aldose Reductase Inhibitors With Antioxidant Activity [PDF]

, 2021
Wenchao Liu, Huan Chen, Xiaonan Zhang, Xin Zhang, Long Xu, Yanqi Lei, Changjin Zhu, Bing Ma   +7 more
openalex   +1 more source

miR‐27a‐3p Upregulation and Netrin‐1 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes

European Journal of Neurology, Volume 32, Issue 12, December 2025.
ABSTRACT Background Inflammation is increasingly recognized in the pathogenesis of diabetic neuropathy (DN). Circulating miR‐27a‐3p levels are closely related to inflammation and increased in patients with diabetic nephropathy and retinopathy. miR‐27a‐3p has a predicted binding site in the 3 UTR of Netrin‐1 mRNA, an anti‐inflammatory nerve growth ...
Asif Mondal, Sucharita Banerjee, Somnath Naskar, Chiranjit Bose, Chinmay Saha, Subhasish Pramanik, Bidisha Mukherjee, Piyali Jati, Pranab Kumar Sahana, Rayaz A. Malik, Satinath Mukhopadhyay   +10 more
wiley   +1 more source

In vitro and in vivo evaluation of pterostilbene for the management of diabetic complications

Journal of Ayurveda and Integrative Medicine, 2020
Background: Aldose reductase (AR) and Advanced glycation end product (AGE) are known to play important roles in the development of diabetic complications. The inhibitors of AR and AGE would be potential agents for the prevention of diabetic complications.
Dilip Dodda, Ajmera Rama Rao, Ciddi Veeresham   +2 more
doaj   +1 more source