Biochemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics [PDF]
, 2010 International audienceMarine plants and animals are sources of a huge number of pharmacologically active compounds, some of which exhibit antineoplastic activity of clinical relevance.
Barthomeuf, Chantal +3 more
core +4 more sources
The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena.
Livia Misuri +6 more
doaj +1 more source
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study [PDF]
, 2000 I. G. Obrosova, Lamia Fathallah
openalex +1 more source
Aldose Reductase Inhibitors from Green Tea
LWT - Food Science and Technology, 1994 Abstract Aldose reductase, which is a key enzyme in the polyol pathway and a target enzyme for the pharmacological control of diabetic complications, was strongly inhibited by a hot-water extract of green tea. The aldose reductase inhibitors in green tea were purified by solvent fractionation, reversed-phase column chromatography, and high ...
Masatsune Murata +2 more
openaire +1 more source
Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective
Annals of Indian Academy of Neurology, 2008 Background: A number of diabetic patients with diabetic neuropathy, in India, were treated with epalrestat, an aldose reductase inhibitor. In this study, more than 2000 patients with diabetic neuropathy, who were treated with epalrestat for 3-12 months,
Sharma S, Sharma Nalini
doaj
Preferential Solvation Study of the Synthesized Aldose Reductase Inhibitor (SE415) in the {PEG 400 (1) + Water (2)} Cosolvent Mixture and GastroPlus-Based Prediction. [PDF]
ACS Omega, 2022 Hussain A +10 more
europepmc +1 more source
Astaxanthin inhibits aldose reductase activity in Psammomys obesus, a model of type 2 diabetes and diabetic retinopathy [PDF]
, 2019 Maha Benlarbi‐Ben Khedher +7 more
openalex +1 more source
Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential [PDF]
, 2017 Chronic inflammation of skeletal muscle tissues termed myositis is associated with inherited muscular dystrophy and with acquired inflammatory myopathy.
De Paepe, Boel
core +1 more source
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats [PDF]
, 1997 Norman E. Cameron +3 more
openalex +1 more source
Repression of Polyol Pathway Activity by Hemidesmus indicus var. pubescens R.Br. Linn Root Extract, an Aldose Reductase Inhibitor: An In Silico and Ex Vivo Study. [PDF]
Nat Prod Bioprospect, 2021 Haroon HB +6 more
europepmc +1 more source