Results 211 to 220 of about 14,544 (270)

Spiro Hydantoin Aldose Reductase Inhibitors

Journal of Medicinal Chemistry, 1988
Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of diabetes mellitus. Spiro hydantoins derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens.
R, Sarges, R C, Schnur, J L, Belletire, M J, Peterson   +3 more
openaire   +2 more sources

The aldose reductase inhibitor site

Metabolism, 1986
Evidence linking the enzyme aldose reductase (alditol:NADP+ oxidoreductase, EC 1.1.1.21) to the pathogenesis of several diabetic complications is rapidly mounting. The results of several animal studies combined with preliminary reports of ongoing clinical trials indicate that inhibition of aldose reductase produces a beneficial effect against such ...
P F, Kador, J H, Kinoshita, N E, Sharpless   +2 more
openaire   +2 more sources

Aldose Reductase Inhibitors: An Update

Annals of Pharmacotherapy, 1993
OBJECTIVE: To update readers on research being conducted with the aldose reductase inhibitor (ARI) tolrestat in treating complications of diabetes mellitus. The article briefly describes early investigations with other ARIs and reviews the more recent studies of tolrestat.
S C, Tsai, T G, Burnakis
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Spiro oxazolidinedione aldose reductase inhibitors

Journal of Medicinal Chemistry, 1982
Spiro oxazolidinediones (2) derived from five- and six-membered ring aralkyl ketones are potent aldose reductase inhibitors in vitro and in vivo. Their novel and general synthesis has been devised with alpha-hydroxyimidates (5) and 4-alkoxy-2-oxo-3-oxazolines (6) as key intermediates, since traditional synthetic routes through alpha-hydroxy amides (8 ...
R C, Schnur, R, Sarges, M J, Peterson
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Nitrophenyl Derivatives as Aldose Reductase Inhibitors

Bioorganic & Medicinal Chemistry, 2002
Nitrophenyl derivatives were recently discovered as a new class of ALR2 inhibitors by means of docking and database screening of the National Cancer Institute database of organic molecules. The nitro group was predicted to bind to the Tyr48 and His110 active site residues of the enzyme, the site where acidic ALR2 inhibitors such as carboxylic acids ...
COSTANTINO, Luca, A. M. Ferrari, GAMBERINI, Maria Cristina, RASTELLI, Giulio   +3 more
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Aldose reductase inhibitors from natural sources

Natural Product Reports, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Jesús Angel, de la Fuente, Sonia, Manzanaro   +1 more
openaire   +2 more sources

Aldose reductase inhibitors: Recent developments

1993
Perfect control of blood glucose levels in diabetic patients might ultimately be achieved with islet or pancreas transplants or with an artificial pancreas. However, to achieve such a goal on a large scale, it will be necessary to overcome the formidable safety or efficacy issues attendant with these approaches (see, e.g., [1, 2]).
R, Sarges, P J, Oates
openaire   +2 more sources

Aldose reductase inhibitors and cataract

International Ophthalmology, 1991
Blindness in diabetics is largely due to retinopathy and/or cataract. Hyperglycaemia and the duration of diabetes are major risk factors for the development of cataract and retinopathy. This review details some of the reactions of glucose that are relevant to the development of complications, and follows the elucidation of monosaccharide autoxidation ...
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Aldose Reductase Inhibitors from the Nature

Current Medicinal Chemistry, 2003
Aldose reductase (AR) is an NADPH dependent enzyme that catalyses the reduction of the aldehyde to the corresponding alcohols. Diabetic complications including neuropathy, nephropathy, cataracts and retinopathy are considerately caused by accumulation of sorbitol, which is produced from glucose by AR in polyol pathway.
K, Kawanishi, H, Ueda, M, Moriyasu
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Selective irreversible inhibitors of aldose reductase

Journal of Medicinal Chemistry, 1992
A series of 5-substituted-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid analogues have been examined as irreversible inhibitors of aldose reductase. The 5-alpha-bromoacetamide and 5-alpha-iodoacetamide analogues 5 and 6 gave irreversible inhibition of aldose reductase while the 5-alpha-chloroacetamide analogue 3 did not show this type of ...
M W, Smar, J J, Ares, T, Nakayama, H, Itabe, P F, Kador, D D, Miller   +5 more
openaire   +2 more sources