Results 221 to 230 of about 14,544 (270)

Aldose Reductase Inhibitors of Plant Origin

Phytotherapy Research, 2013
Diabetic complications are attributed to hyperglycaemic condition which is in turn associated with the polyol pathway and advanced glycation end products. Aldose reductase (AR) is the principal enzyme of polyol pathway which plays a vital role in the development of diabetic complications.
Ciddi, Veeresham, Ajmeera, Rama Rao, Kaleab, Asres   +2 more
openaire   +2 more sources

[Aldose reductase inhibitors].

Journal de pharmacologie, 1987
Aldose reductase (AR) is an enzyme which catalyzes the transformation of D-glucose to sorbitol. Under non physiological conditions, like diabetes for example, the accumulation of polyols in the lens, sorbitol in particular, gives a basis to the osmotic hypothesis of cataract formation. AR inhibitors can protect against such accumulation.
P, Dostert, M, Strolin Benedetti
openaire   +1 more source

Aldose reductase inhibitors and diabetic complications

Pharmacology & Therapeutics, 1992
Aldose reductase inhibitors impede flux of glucose through the sorbitol pathway in diabetes mellitus. They therefore reduce the accumulation of the pathway metabolites, sorbitol and fructose, reduce the impact of the flux on the cofactors used by the pathway and reduce other derived phenomena, such as osmotic stress and myo-inositol depletion. As drugs,
TOMLINSON, DR, WILLARS, GB, CARRINGTON, AL   +2 more
openaire   +3 more sources

Inhibition of aldehyde reductase by aldose reductase inhibitors

Biochemical Pharmacology, 1990
A broad group of structurally diverse aldose reductase inhibitors including flavonoids, carboxylic acids and hydantoins, have been examined for their ability to inhibit rat kidney aldehyde reductase (EC 1.1.1.19, EC 1.1.1.20) versus rat lens aldose reductase (EC 1.1.1.21).
S, Sato, P F, Kador
openaire   +2 more sources

Curcumin Analogues as Potent Aldose Reductase Inhibitors.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Zhi-Yun, Du, Ya-Dan, Bao, Zhong, Liu, Wei, Qiao, Lin, Ma, Zhi-Shu, Huang, Lian-Quan, Gu, Albert S C, Chan   +7 more
openaire   +2 more sources

Clinical trials with aldose reductase inhibitors

Experimental Eye Research, 1990
Following the identification of potent, orally active inhibitors of aldose reductase, the next challenge comes in demonstrating clinical utility in the treatment of diabetic complications. It is not feasible to conduct pivotal studies in all indications within the same trial and neuropathy evolved as the lead indication.
openaire   +2 more sources

Flavonoids as Inhibitors of Lens Aldose Reductase

Science, 1975
Flavonoids are effective inhibitors of lens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing
S D, Varma, I, Mikuni, J H, Kinoshita
openaire   +2 more sources

Aldose Reductase / Polyol Inhibitors for Diabetic Retinopathy

Current Pharmaceutical Biotechnology, 2011
Diabetic retinopathy is the most common microvascular complication of diabetes and the most severe of diabetic ocular complications. This review describes retinal changes at different stages of diabetic retinopathy and risk factors associated with this devastating disease.
Irina G, Obrosova, Peter F, Kador
openaire   +2 more sources

Molecular Modeling Studies of Aldose Reductase Inhibitors

Journal of Medicinal Chemistry, 1994
Molecular modeling studies using the AM1 quantum chemical method and a torsional fitting method have been conducted on a series of aldose reductase inhibitors (ARIs) possessing an ionizable group and/or functional group susceptible to nucleophilic attack with the aim of defining the spatial position of ARI pharmacophores.
Y S, Lee, R, Pearlstein, P F, Kador
openaire   +2 more sources

Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors

Current Eye Research, 1982
The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells.
S K, Srivastava, J M, Petrash, I J, Sadana, N H, Ansari, C A, Partridge   +4 more
openaire   +2 more sources