Results 31 to 40 of about 14,544 (270)

Docking studies: In silico aldose reductase inhibitory activity of commercially available flavonoids

Bangladesh Journal of Pharmacology, 2012
New drugs for the inhibition of the enzyme aldose reductase are in development and they have to be screened before being considered for preclinical and clinical evaluation.
Muthuswamy Umamaheswari, C. S. Aji, Kuppuswamy Asokkumar, Thirumalaisamy Sivsshanmugam, Varadharajan Subhadradevi, Puliyath Jagannath, Arumugam Madeswaran   +6 more
doaj   +1 more source

Computational screening identifies selective aldose reductase inhibitors with strong efficacy and limited off target interactions. [PDF]

Sci Rep
Rojas JJ, Pestana-Nobles R, Pacheco-Londono LC, Utria-Munive J, Galan-Freyle NJ.   +4 more
europepmc   +3 more sources

Identification of a novel polyfluorinated compound as a lead to inhibit human enzymes aldose reductase and AKR1B10 : structure determination of both ternary complexes and implications for drug design [PDF]

, 2014
Aldo-keto reductases (AKRs) are mostly monomeric enzymes which fold into a highly conserved ([alpha]/[beta])8 barrel, while their substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable
Adams, Alberto Podjarny, Alexandra Cousido-Siah, André Mitschler, Ballatore, Barski, Barski, Biadene, Bohren, Calderone, Cao, Chung, Costantino, Darden, Dunitz, Díez-Dacal, El-Kabbani, El-Kabbani, El-Kabbani, Emsley, Endo, Endo, Endo, Felix Terwesten, Fenical, Francesc X. Ruiz, Fuente, Fuente, Fuhrmann, Fukumoto, Gallego, Gallego, Gerhard Klebe, Gregson, Götz, Harrison, Hernandes, Hornak, Howard, Huggins, Humphrey, Jakalian, Jakalian, Jarman, Jaume Farrés, Jesús A. de la Fuente, Jorgensen, Kim, Kipper, Lamour, Le Grand, Lecomte, Liu, Loncharich, Lovering, Ma, Manzanaro, María J. Martín, Matsunaga, Michael Betz, Murshudov, Navaza, O'Boyle, Oates, Otwinowski, Parisini, Penning, Podjarny, Quinn, Ramana, Ramunno, Rastelli, Rastelli, Rayment, Rayment, Roe, Ruiz, Ruiz, Ruiz, Ryckaert, Salomon-Ferrer, Sergio Porté, Sheldrick, Shinde, Sledz, Soda, Soda, Sonia Manzanaro, Steuber, Takemura, Tammali, Tang, Urzhumtsev, Verma, Walter, Wang, Wang, Wang R Wang G Ricard M J Ferris B Strulovici-Barel Y Salit J Hackett N R Gudas L J & Crystal R G, Xavier Parés, Yadav, Zeindl-Eberhart, Zhang, Zhao, Ángel R. de Lera   +103 more
core   +3 more sources

Prevention of Protein Glycation by Natural Compounds [PDF]

, 2015
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan.
Bartosz, Grzegorz, Sadowska-Bartosz, Izabela   +1 more
core   +2 more sources

Hyperglycemia Impairs Acetylcholine-Induced Vasodilation of Retinal Arterioles Through Polyol Pathway–Independent Mechanisms in Rats

Journal of Pharmacological Sciences, 2010
We previously reported that acetylcholine (ACh)–induced vasodilation of retinal arterioles is diminished in diabetic rats; however, the underlying mechanism(s) of this phenomenon has not been fully elucidated.
Asami Mori, Orie Saigo, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii   +4 more
doaj   +1 more source

Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies.
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti   +10 more
doaj   +1 more source

Multiprotein Inhibitory Effect of Dietary Polyphenol Rutin from Whole Green Jackfruit Flour Targeting Different Stages of Diabetes Mellitus: Defining a Bio-Computational Stratagem

Separations, 2022
The anti-diabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed) was investigated using inhibitory assays for α-glucosidase, α-amylase, aldose reductase, and glycation at multiple stages.
Tejaswini Maradesha, Shashank M. Patil, Bhaskar Phanindra, Raghu Ram Achar, Ekaterina Silina, Victor Stupin, Ramith Ramu   +6 more
doaj   +1 more source

PocketPicker: analysis of ligand binding-sites with shape descriptors [PDF]

, 2007
Background Identification and evaluation of surface binding-pockets and occluded cavities are initial steps in protein structure-based drug design.
Proschak, Ewgenij, Schneider, Gisbert (Prof. Dr.), Weisel, Martin   +2 more
core   +3 more sources

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

Metabolites, 2021
Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated.
Francesc Xavier Ruiz, Xavier Parés, Jaume Farrés   +2 more
doaj   +1 more source

Aldose reductase regulates microglia/macrophages polarization through the cAMP response element-binding protein after spinal cord injury in mice. [PDF]

, 2016
Inflammatory reactions are the most critical pathological processes occurring after spinal cord injury (SCI). Activated microglia/macrophages have either detrimental or beneficial effects on neural regeneration based on their functional polarized M1/M2 ...
Bian, Ganlan, Chen, Peng, Chung, Sookja K., Ju, Gong, Liu, Fangfang, Liu, Ling, Song, Bing, Wang, Jian, Xue, Qian, Yu, Caiyong, Zhang, Qian   +10 more
core   +1 more source