Results 51 to 60 of about 14,544 (270)

Structure-Guided Identification and Evaluation of Epalrestat and Ranirestat-Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy. [PDF]

ChemistryOpen
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Khan MS, Yadav DK, Shahwan M, Shamsi A.
europepmc   +2 more sources

Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]

, 2020
Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara, Nwadozi, Emmanuel, Rudnicki, Martina   +2 more
core   +1 more source

Bioenergetics in diabetic neuropathy: what we need to know [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91209/1/j.1529-8027.2012.00389.x ...
Boulton, Brownlee, Chisholm, Du, Du, Edwards, Epidemiology of Diabetes Interventions and Complications (EDIC), Erecinska, Feldman, Feldman, Gardiner, Gardner, Gardner, Greene, Greene, Greene, Greene, Greene, Greene, Izawa, Johnson, Kern, Kishi, Magnani, Murea, Nishikawa, Obrosova, Ola, Said, Shun, Simpson, Stevens, Sullivan, Thurston, Tomlinson, Tretter, Tretter, Tsai, van de Weijer, Vincent, Vincent, Vincent, Vincent, Vincent, Vincent, Young, Yudkoff   +46 more
core   +1 more source

Discovery of new selective human aldose reductase inhibitors through virtual screening multiple binding pocket conformations [PDF]

, 2013
Aldose reductase reduces glucose to sorbitol. It plays a key role in many of the complications arising from diabetes. Thus, aldose reductase inhibitors (ARI) have been identified as promising therapeutic agents for treating such complications of diabetes,
Gu, Q, Hagler, A, Hu, X, Li, J, Liu, Z, Wang, L, XU, J, Ye, J, Zheng, X   +8 more
core   +1 more source

Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Reduces Sorbitol Levels and Improves Motor Nerve Conduction Velocity in Streptozotocin-Diabetic Rats

Journal of Pharmacological Sciences, 2008
Ranirestat (AS-3201) is a novel aldose reductase (AR) inhibitor with potentially beneficial effects on diabetic sensorimotor polyneuropathy. In this study, we performed a kinetic analysis to determine the mode of inhibition of ranirestat on AR and ...
Takafumi Matsumoto, Yoshiyuki Ono, Masuo Kurono, Akemi Kuromiya, Keiji Nakamura, Vera Bril   +5 more
doaj   +1 more source

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]

, 2014
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results
Armand, Lucie, Aude-Garcia, Catherine, Carrière, Marie, Collin-Faure, Véronique, Diemer, Hélène, Gerdil, Adèle, Habert, Aurélie, Hanau, Daniel, Herlin, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +13 more
core   +4 more sources

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Aldose Reductase Inhibition, Molecular Docking, and Density Functional Theory Studies of Dinaphthodiospyrol H from Diospyros kaki (Japanese Persimmon)

Journal of Pure and Applied Microbiology
This study explores the aldose reductase (AR) inhibitory potential of dinaphthodiospyrol H, a compound isolated from Diospyros kaki (Japanese persimmon).
Abdur Rauf, Saima Naz, Zubair Ahmad, Umer Rashid, Marryum, Khurshid Ayub, Muhammad Aetizaz, Ho Soonmin, Naveed Muhammad, Mujeeb-ur-Rehman, Walaa F. Alsanie, Abdulhakeem S. Alamri   +11 more
doaj   +1 more source

Inositols in Insulin Signaling and Glucose Metabolism [PDF]

, 2018
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of
Bevilacqua, Arturo, Bizzarri, Mariano
core   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source