Results 71 to 80 of about 14,544 (270)
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu +7 more
wiley +1 more source
Evaluation of Pharmacokinetic Parameters, Toxicity, and Molecular Docking of Flavonols with Aldose Reductase Enzyme to Find an Effective Compound in Inhibition of this Enzyme [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Aldose reductase plays an important role in chronic diabetes and can cause tissue complications. Controlling the activity of aldose reductase provides an important strategy in controlling the complications of diabetes.
Morteza Sadeghi, Mehran Miroliaei
doaj
糖尿病性心筋症に対するフルバスタチン長期投与の効果ー抗酸化作用および冠微小循環から見た検討ー [PDF]
, 2014 富山大学・富医薬博乙第49号・志田拓也・2014/03/26Heart Vessels,2014,29(4),532 ...
志田 拓也
core +2 more sources
Recent Advances in the Bioactive Compounds of Prunes (Prunus domestica L.) and Their Health Benefits
Food Frontiers, Volume 7, Issue 1, January 2026.Prunes (Prunus domestica L.) are a functional food rich in diverse bioactive compounds, including polyphenols (such as chlorogenic acid and anthocyanins), polysaccharides, and sorbitol.This review comprehensively synthesizes current research on the nutritional composition and biological activities of prunes, highlighting their multifaceted health ...
Luyang Han +10 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2022 Ranirestat, an aldose reductase inhibitor evaluated in several randomised controlled trials (RCTs) in diabetic peripheral neuropathy (DPN). However, to date, no meta-analysis has evaluated the efficacy and safety of ranirestat in DPN.
Deep Dutta +4 more
doaj +1 more source
Pyrrolylbenzothiazole Derivatives as Aldose Reductase Inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2002 Activation of the aldose reductase enzyme (AR, ALR2, E.C. 1.1.1.21) of the polyol pathway has suggested that it is implicated in a number of pathological conditions: a) in diabetic patients, for the development of the long term complications of the disease, and b) in non diabetic individuals, for ischemic myocardial injury, for abnormal proliferation ...
Nazlaa, Zaher +2 more
openaire +2 more sources
Molecular Ecology, Volume 35, Issue 2, January 2026.ABSTRACT Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early‐life developmental stress. Japanese quail Coturnix japonica) males produce a unique seminal foam that enhances fertilisation success.
Chloe Mason +6 more
wiley +1 more source
Safety, Tolerability and Pharmacokinetics of Single-Dose Oral SYHA1402 in Healthy Chinese Subjects
Neurology and Therapy, 2023 Introduction To assess the safety, tolerability and pharmacokinetics of a single dose of SYHA1402 in healthy Chinese subjects. Methods This was a randomized, double-blind, placebo-controlled, single-ascending dose study in healthy subjects.
Beibei Liang +4 more
doaj +1 more source
The betaine/GABA transporter and betaine: roles in brain, kidney, and liver [PDF]
, 2014 The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium symporter transporter family) and mediates cellular uptake of betaine and GABA ...
Niels C. Danbolt +2 more
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Andrologia, Volume 2026, Issue 1, 2026.The proteomic analysis of seminal plasma (SP) is a powerful tool for screening and identifying potential novel biomarkers of male infertility. However, the proteomic composition of seminal extracellular (SE) vesicles in varicocele (VC) is still poorly characterized.
Cheng Yang +7 more
wiley +1 more source