Results 81 to 90 of about 14,544 (270)

Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor [PDF]

Brain, 2001
The present study was designed to examine the effect of aldose reductase (AR) overexpression on the development of diabetic neuropathy by using mice transgenic for human AR. At 8 weeks of age, transgenic mice (Tg) and non-transgenic littermates (Lm) were made diabetic with streptozotocin.
S, Yagihashi, S I, Yamagishi, R, Wada Ri, M, Baba, T C, Hohman, C, Yabe-Nishimura, Y, Kokai   +6 more
openaire   +2 more sources

Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification. [PDF]

, 2016
Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice.
Cao, Yan, Chai, Yifeng, Chen, Xiaofei, Dan, Jia, Diao, Yong, Gao, Shouhong, Guo, Zhiying, Wu, Xunxun, Zerbe, Philipp, Zhang, Lei   +9 more
core   +1 more source

Qinggan Mingshi Granules Inhibited Ferroptosis to Treat Diabetic Retinopathy in Mice Through NRF2/GPX4 Axis

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Diabetic retinopathy (DR) is a common microvascular complication of diabetes, which seriously affected the life quality in diabetic patients. Developing novel therapy to improve DR is essential. Qinggan Mingshi granules (QGMS) have been demonstrated with protective effects on DR clinically.
Zhongyong Zhang, Qianqian Jin, Hongmin Zhao, Yingkai Liu, Meng Wang, Zhongqian Han, Jin Wu, Shuquan Lv, Xiaoyun Wang, Wei Chen, Qingjin Wang, Hailong Bai, Yuansong Wang, Weibo Wen   +13 more
wiley   +1 more source

Up-regulation of aldose reductase activity in cultured mesangial cells overexpressing human aldose reductase gene is associated with increased TGF-beta1 and collagen IV expression [PDF]

, 2003
published_or_final_versio
Chung, SK, Chung, SSM, Dan, QH, Lam, KSL, Wong, R, Yin, SN   +5 more
core  

Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Maturation in Aged Mice: A Multitarget Mechanistic Study Using Network Pharmacology and Molecular Simulations

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Mitochondrial dysfunction plays a critical role in ovarian aging and the associated decline in female fertility. Nicotinamide riboside (NR), a vitamin B3 derivative and dietary NAD+ precursor, has shown antiaging potential, yet its molecular mechanisms in ovarian function are not fully understood.
Ningyu Sun, Xiang Cheng, Lu Lu, Wuwen Zhang, Kai Li, Yuanyuan Chen, Yun Li, Chunling Liu, Qinhua Zhang, Ping Yin, Anupama Bose   +10 more
wiley   +1 more source

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

Heterocyclic Communications, 2021
In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts.
Yin Liang, Zhang Mingxue, He Tiangeng
doaj   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, Volume 72, Issue 6, Page 1752-1762, December 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

Demethoxylated curcuminoids as antidiabetic complication drug leads – in silicostudies [PDF]

African Journal of Pharmaceutical Research and Development (AJOPRED)
Curcuma longa is used traditionally in the treatment of diabetes and diabetic complications. Aldose Reductase (ALR2) inhibition is a  plausible therapeutic strategy against diabetic complications.
Olusegun Samson Ajala, Dolapo Omolade Innocent-Ugwu, Peace Udodiri Okechukwu, Olayinka Hannah Dada   +3 more
doaj   +2 more sources

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Integrated network pharmacology, molecular docking, and dynamics simulations revealed the anti‐osteoarthritis mechanism of Ermiao San. Key bioactive compounds (e.g., quercetin) synergistically target core proteins (e.g., TNF and IL‐6), modulating critical pathways (e.g., TNF signaling) to inhibit inflammation and cartilage degradation, demonstrating a ...
Zhenyu Song, Jincheng Huang, He Zhu, Xu Li, Qianqian Cao, Liyang Yang, Meng Zhang, Hongkai Wang, Haoyue Sun   +8 more
wiley   +1 more source