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1989
Alexander’s disease (AD) is a rare, nonfamilial disorder of the nervous system which is also called dysmyelinogenetic leukodystrophy. The disease occurs sporadically without clear familial incidence. Three clinical subgroups of AD can be distinguished: infantile, juvenile and adult.
Jacob Valk, Marjo S. van der Knaap
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Alexander’s disease (AD) is a rare, nonfamilial disorder of the nervous system which is also called dysmyelinogenetic leukodystrophy. The disease occurs sporadically without clear familial incidence. Three clinical subgroups of AD can be distinguished: infantile, juvenile and adult.
Jacob Valk, Marjo S. van der Knaap
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Computed tomography in Alexander's disease
Annals of Neurology, 1984AbstractComputed tomography demonstrated contrast‐enhancing lesions in the periventricular frontal regions, caudate nuclei, and thalami in an infant with Alexander's disease. The distribution of the enhancing lesions corresponded to the areas in which Rosenthal fibers were most prominent.
K, Farrell, S, Chuang, L E, Becker
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2014
Alexander's disease can occur at any age. Children typically present with delayed development, seizures, and macrocephaly, whereas older patients generally display bulbar symptoms. Myelin defects can be severe in younger patients, but subtle or absent in older patients.
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Alexander's disease can occur at any age. Children typically present with delayed development, seizures, and macrocephaly, whereas older patients generally display bulbar symptoms. Myelin defects can be severe in younger patients, but subtle or absent in older patients.
openaire +1 more source
Neuropsychological Functioning in Alexander Disease: A Case Series
Child Neurology Open, 2021Alexandra C Kirsch +2 more
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Developmental Profiles in Children and Young Adults with Alexander Disease
Developmental Neurorehabilitation, 2023Laura Zampini, Paola Zanchi
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Disorders of Astrocytes: Alexander Disease as a Model
Annual Review of Pathology: Mechanisms of Disease, 2017James E Goldman
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Alexander's disease in infancy and childhood: a report of two cases
Acta Neuropathologica, 1992J W Neal, S K Singhrao, G Cole
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