Results 31 to 40 of about 77 (63)

Introduction: A Mnemosyne of Art & Science

open access: yes
Renaissance Studies, EarlyView.
Ana Duarte Rodrigues   +2 more
wiley   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy   +4 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić   +7 more
wiley   +1 more source

Salt crystallization damage in limestone used in historical buildings:an experimental comparison between Italian and Greek stones.

open access: yes, 2019
Water and salts have long been the main factors of deterioration in building materials. This thesis studies the weathering resistance of limestone as a building material under salt crystallization conditions. Specimens selected were Alfas stone and Lecce
Ren, Yuanhang
core  

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik   +44 more
wiley   +1 more source

Tinkering Towards Sustainability: Bundling Innovations to Electrify the Fossil‐Dependent Process Industry

open access: yesCreativity and Innovation Management, Volume 35, Issue 2, Page 356-373, June 2026.
ABSTRACT Sustainability transitions, such as electrifying the process industry, require a bundle of related innovations to make meaningful progress. Drawing on literature on innovation through tinkering, that is, adaptive, typically small‐scale experimentation with various forms of innovation, and applying a micropolitical perspective, this qualitative
Karin Wigger   +3 more
wiley   +1 more source

A Common Reference Material for Mass‐Dependent Sn Isotope Compositions: An Inter‐Laboratory Calibration Approach

open access: yesGeostandards and Geoanalytical Research, Volume 50, Issue 2, Page 341-367, June 2026.
Key Points We recommend using the notation δ122/118SnNIST SRM 3161a for mass‐dependent Sn isotope data. We derived conversion factors relative to NIST SRM 3161a for Puri Sn CEZA (0.132 ± 0.011‰), Sn Lyon (0.229 ± 0.016‰), Sn IPGP (0.162 ± 0.018‰). Tin isotope compositions are presented for SPEX CertiPrep Sn and nine USGS reference materials.
Aurélia C.E. Meister   +10 more
wiley   +1 more source

Two Pathways to Proletarianization: Understanding Professionals' Adaptation to the “Corporatization” of Chinese Law Firms

open access: yesSociological Forum, Volume 41, Issue 2, Page 291-307, June 2026.
ABSTRACT This study examines how lawyers in China adapt to the “corporatization” of law firms, which limits their professional autonomy within bureaucratic structures. “Proletarianization” theory, which emerged in the 1970s, effectively explains employment relations and internal stratification within the legal profession, but it has been underestimated
Xinyi Shen
wiley   +1 more source

Plenary Abstracts Session & Oral Presentations

open access: yes
HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

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