Results 111 to 120 of about 11,984,557 (361)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

On Holt's Algorithm

Journal of Symbolic Computation, 1993
\textit{D. F. Holt} [Comput. group theory, Proc. Symp., Durham 1982, 307-319 (1984; Zbl 0544.20004)] has described an algorithm for the computation of the Schur multiplier of a permutation group \(G\). As one of the steps, after finding a Sylow subgroup \(P\) of \(G\), he needs a power-commutator presentation of \(P\) in order to use collection methods
John Cannon, Greg Butler
openaire   +2 more sources

Plant Species Recognition Using Triangle-Distance Representation

IEEE Access, 2019
Plant species recognition using leaf images is a highly important and challenging issue in botany and pattern recognition. A center problem of this task is how to accurately extract leaf image characteristics and quickly calculate the similarity between ...
Chengzhuan Yang, Hui Wei
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Advancements in Large-Scale Image and Text Representation Learning: A Comprehensive Review and Outlook

IEEE Access
Large-scale image and text representation learning is critical in determining the performance of multimodal tasks involving images and text, such as visual question answering and image captioning.
Yang Qin, Shuxue Ding, Huiming Xie
doaj   +1 more source

Selective Random CDD Enhanced Joint Cooperative Relay and HARQ for Delay-Tolerant Vehicular Communications

International Journal of Distributed Sensor Networks, 2015
We propose a selective random cyclic-delay diversity (CDD) enhanced joint cooperative relay and hybrid automatic repeat request (HARQ) scheme for two-hop vehicular communications.
Gang Wu, Qinghe Du, Kun Hua
doaj   +1 more source

A Limited Memory Algorithm for Bound Constrained Optimization

SIAM Journal on Scientific Computing, 1995
An algorithm for solving large nonlinear optimization problems with simple bounds is described. It is based on the gradient projection method and uses a limited memory BFGS matrix to approximate the Hessian of the objective function.
R. Byrd, P. Lu, J. Nocedal, C. Zhu
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source