Results 61 to 70 of about 10,989,460 (301)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Algorithmic debugging and trusted functions [PDF]
, 2007 As the name states, trusted functions do not have bugs. It is up to user to specify which function is trusted. Commonly used functions in standard library are normally trusted. In the process of algorithmic debugging, we search for faulty nodes to locate
Luo, Yong, Chitil, Olaf
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Pakistan Armed Forces Medical JournalObjective: To evaluate the demographic patterns, frequency, and etiological profile of proptosis in patients presenting to a tertiary care eye hospital, and to develop an algorithmic approach for its diagnosis and management.
Aisha Rafique +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Frontiers in PsychologyAlgorithmic evaluation plays a pivotal role in regulating gig workers’ job performance; however, extant studies have reported inconsistent findings regarding its effects.
Xinyu Teng, Huan Tao, Chuntong Dong
doaj +1 more source
Two-dimensional Kolmogorov complexity and an empirical validation of the Coding theorem method by compressibility [PDF]
PeerJ Computer Science, 2015 We propose a measure based upon the fundamental theoretical concept in algorithmic information theory that provides a natural approach to the problem of evaluating n-dimensional complexity by using an n-dimensional deterministic Turing machine.
Hector Zenil +3 more
doaj +2 more sources
Play, Algorithmic Thinking and Early Childhood Education: Challenges in the Portuguese Context [PDF]
, 2021 ALGOLITTLE is an EU-funded project, with partners from Portugal, Italy, Turkey, and Slovenia, supporting the integration of algorithmic thinking skills into preschool education for preparing future code literates from an early age. The paper presents the
Cristina Azevedo Gomes +13 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source