Results 71 to 80 of about 386,495 (263)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Аlgorithmic and Conceptual Approach to Figure Surface Measurement

Inovacije u Nastavi, 2019
Surface measurement is an important topic of the school curricula which is closely related to other mathematical topics and to the real world. The results of numerous international studies show that students' achievements in the area of surface ...
Marijana Ž. Zeljić, Milica R. Ivančević   +1 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An Algorithmic Approach to Chain Recurrence [PDF]

Foundations of Computational Mathematics, 2005
In this paper we give a new definition of the chain recurrent set of a continuous map using finite spatial discretizations. This approach allows for an algorithmic construction of isolating blocks for the components of Morse decompositions which approximate the chain recurrent set arbitrarily closely as well as discrete approximations of Conley's ...
Kalies, W.D., Mischaikow, K., van der Vorst, R.C.A.M.   +2 more
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

An algorithmic approach to the existence of ideal objects in commutative algebra

, 2019
The existence of ideal objects, such as maximal ideals in nonzero rings, plays a crucial role in commutative algebra. These are typically justified using Zorn's lemma, and thus pose a challenge from a computational point of view.
C Mulvey, D Rinaldi, D Rinaldi, D Rinaldi, D Rinaldi, Davide Rinaldi, F Richman, G Kreisel, G Kreisel, G Kreisel, H Lombardi, H Schwichtenberg, I Yengui, I Yengui, J Cederquist, M Atiyah, M Coste, P Oliva, P Oliva, P Schuster, P Schuster, S Negri, S Sanders, SG Simpson, U Berger, U Berger, U Kohlenbach, U Kohlenbach, U Kohlenbach, U Kohlenbach, U Kohlenbach, U Kohlenbach, Von Kurt Gödel, Y Gurevich   +33 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Algorithmic Gossiping: sharing and non-sharing that evolve algorithmic imaginaries to folk theories

Information Research: An International Electronic Journal
Introduction. This paper presents a work-in-progress diary study exploring how algorithmic gossiping contributes to the transformation of individual, momentary algorithmic imaginaries into shared and consolidated folk theories. Method.
Gaohui Cao, Zhang Wen, Puyi Liu
doaj   +1 more source

Assessing the impact of algorithmic trading on markets: a simulation approach [PDF]

, 2008
Innovative automated execution strategies like Algorithmic Trading gain significant market share on electronic market venues worldwide, although their impact on market outcome has not been investigated in depth yet.
Gsell, Markus
core   +1 more source