Results 71 to 80 of about 282,088 (296)

Information Fusion for Anomaly Detection with the Dendritic Cell Algorithm [PDF]

, 2010
Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system, providing the initial detection of pathogenic invaders.
Aickelin, Uwe, Greensmith, Julie, Tedesco, Gianni   +2 more
core   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Beyond algorithm aversion: How users trade off decisional agency and optimal outcomes when choosing between algorithms and human decision-makers

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
By definition, algorithmic decision-making (ADM) transfers human agency (i.e., decisional control) to the machine in exchange for optimal outcomes. Whereas algorithmic aversion literature suggests a default hesitance to use machine decisions, these ...
Gabi Schaap, Tibor Bosse, Paul Hendriks Vettehen   +2 more
doaj   +1 more source

Algorithms for Lattice QCD with Dynamical Fermions

, 2004
We consider recent progress in algorithms for generating gauge field configurations that include the dynamical effects of light fermions. We survey what has been achieved in recent state-of-the-art computations, and examine the trade-offs between ...
A.D. Kennedy, Arnold, Aubin, Bode, Boriçi, Boriçi, Boriçi, Boriçi, Brower, Bunk, Chen, Chiu, Chiu, Chiu, Clark, Clark, Clark, Cundy, Cundy, de Forcrand, Dürr, Edwards, Edwards, Edwards, Farchioni, Fleming, Fodor, Fodor, Frommer, Furman, Gottlieb, Hart, Hasenbusch, Hasenfratz, Hasenfratz, Hernandez, Horváth, Jansen, Joó, Kamleh, Krieg, Liu, Lüscher, Lüscher, Lüscher, Lüscher, Morningstar, Namekawa, Neuberger, Sexton, Ukawa, van den Eshof, Vranas   +52 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

From Disciplinary Societies to Algorithmic Control: Rethinking Foucault’s Human Subject in the Digital Age

Philosophies
In the digital age, the mechanisms of power and control have evolved beyond Foucault’s disciplinary societies, giving rise to a new paradigm of algorithmic governance. This study critically reinterprets Foucault’s concept of the human subject in light of
Hayarpi Sahakyan, Ashot Gevorgyan, Arpine Malkjyan   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Fundamental organometallic reactions: Applications on the CYBER 205 [PDF]

, 1984
Two of the most challenging problems of Organometallic chemistry (loosely defined) are pollution control with the large space velocities needed and nitrogen fixation, a process so capably done by nature and so relatively poorly done by man (industry ...
Rappe, A. K.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Stabilization of mechanical systems using controlled Lagrangians [PDF]

, 1997
We propose an algorithmic approach to stabilization of Lagrangian systems. The first step involves making admissible modifications to the Lagrangian for the uncontrolled system, thereby constructing what we call the controlled Lagrangian.
Bloch, Anthony M., Leonard, Naomi Ehrich, Marsden, Jerrold E.   +2 more
core