Results 71 to 80 of about 4,793 (299)

An accelerated randomized Kaczmarz algorithm [PDF]

Mathematics of Computation, 2015
The randomized Kaczmarz ( R K \rm {RK} )
Ji Liu 0002, Stephen J. Wright 0001
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Dimension-adaptive bounds on compressive FLD Classification [PDF]

, 2013
Efficient dimensionality reduction by random projections (RP) gains popularity, hence the learning guarantees achievable in RP spaces are of great interest.
Kabán, Ata, Robert J. Durrant, Ata Kabán, Durrant, Robert J.   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Quasi-randomness and algorithmic regularity for graphs with general degree distributions [PDF]

, 2010
We deal with two intimately related subjects: quasi-randomness and regular partitions. The purpose of the concept of quasi-randomness is to express how much a given graph “resembles” a random one.
Schacht, Mathias, Alon, Noga, Coja-Oghlan, Amin, Kang, Mihyun, Rödl, Vojtěch, Hàn, Hiêp   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Algorithmic Randomness and Fourier Analysis [PDF]

, 2019
Suppose 1 This is a manuscript of an article published as Franklin, J.N.Y., McNicholl, T.H. & Rute, J. Algorithmic Randomness and Fourier Analysis. Theory Comput Syst 63, 567–586 (2019). doi: 10.1007/s00224-018-9888-8. Posted with permssion.
McNicholl, Timothy, Rute, Jason, Franklin, Johanna   +2 more
core   +1 more source

Computationally Efficient Transductive Machines [PDF]

, 2000
In this paper we propose a new algorithm for providing confidence and credibility values for predictions on a multi-class pattern recognition problem which uses Support Vector machines in its implementation.
Gammerman, A., Vovk, V., Volodya Vovk, Craig Saunders, Alex Gammerman, Saunders, C.   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Normality in non-integer bases and polynomial time randomness [PDF]

, 2017
It is known that if $x\in[0,1]$ is polynomial time random then x is normal in any integer base greater than one. We show that if x is polynomial time random and \beta>1 is Pisot, then x is "normal in base beta", in the sense that the sequence $(x \beta^n)
Figueira, Santiago
core