Results 51 to 60 of about 243 (214)

An accelerated randomized Kaczmarz algorithm [PDF]

Mathematics of Computation, 2015
The randomized Kaczmarz ( R K \rm {RK} )
Ji Liu 0002, Stephen J. Wright 0001
openaire   +3 more sources

Multi-robot path planning based on a deep reinforcement learning DQN algorithm

CAAI Transactions on Intelligence Technology, 2020
The unmanned warehouse dispatching system of the ‘goods to people’ model uses a structure mainly based on a handling robot, which saves considerable manpower and improves the efficiency of the warehouse picking operation. However, the optimal performance
Yang Yang, Li Juntao, Peng Lingling
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Adjusted Kolmogorov Complexity of Binary Words with Empirical Entropy Normalization

Entropy
Kolmogorov complexity of a finite binary word reflects both algorithmic structure and the empirical distribution of symbols appearing in the word. Words with symbol frequencies far from one half belong to smaller combinatorial classes and therefore ...
Brani Vidakovic
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Measuring Fairness in Competitive Entertainment Program Evaluation Mechanisms and Exploring Multi-Factor Driving Characteristics [PDF]

ITM Web of Conferences
To address the systemic conflict between professional scoring and public aesthetics in competitive entertainment programs, this study constructs a reverse-engineering framework for measuring evaluation mechanism fairness and identifying multi-factor ...
Yu Dian, Zou Zijun, Liu Zilv, Li Tongxin
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Hash Tables as Engines of Randomness at the Limits of Computation: A Unified Review of Algorithms

Algorithms
Hash tables embody a paradox of deterministic structure that emerges from controlled randomness. They have evolved from simple associative arrays into algorithmic engines that operate near the physical and probabilistic limits of computation. This review
Paul A. Gagniuc, Mihai Togan
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source