Results 41 to 50 of about 207,048 (241)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On Elementary Computability-Theoretic Properties of Algorithmic Randomness [PDF]
, 2001 In this paper we apply some elementary computability-theoretic notions to algorithmic complexity theory with the aim of understanding the role and extent of computability techniques for algorithmic complexity theory. We study some computability-theoretic
Arslanov, Asat
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2015 The complexity or randomness of the laminar-turbulent transition process of an inlet boundary layer in a circular pipe was analyzed by use of Kolmogorov complexity which is a very important measure of the randomness of various events. In the inlet region
Masashi ICHIMIYA +2 more
doaj +1 more source
Probabilistic Analysis of Pattern Formation in Monotonic Self-Assembly. [PDF]
PLoS ONE, 2015 Inspired by biological systems, self-assembly aims to construct complex structures. It functions through piece-wise, local interactions among component parts and has the potential to produce novel materials and devices at the nanoscale.
Tyler G Moore +2 more
doaj +1 more source
An Algorithmic Approach to Information and Meaning [PDF]
, 2011 While it is legitimate to study ideas and concepts related to information in their broadest sense, that formal approaches properly belong in specific contexts is a fact that is too often ignored. That their use outside these contexts amounts to misuse or
Zenil, Hector
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Multi-robot path planning based on a deep reinforcement learning DQN algorithm
CAAI Transactions on Intelligence Technology, 2020 The unmanned warehouse dispatching system of the ‘goods to people’ model uses a structure mainly based on a handling robot, which saves considerable manpower and improves the efficiency of the warehouse picking operation. However, the optimal performance
Yang Yang, Li Juntao, Peng Lingling
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source