Results 21 to 30 of about 27,881 (287)

Backpropagating Hybrid Monte Carlo algorithm for fast Lefschetz thimble calculations

Journal of High Energy Physics, 2022
The Picard-Lefschetz theory has been attracting much attention as a tool to evaluate a multi-variable integral with a complex weight, which appears in various important problems in theoretical physics.
Genki Fujisawa, Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Formal naive Dirac operators and graph topology

Journal of High Energy Physics
Motivated by a recent conjecture of Misumi and Yumoto relating the number of zero modes of lattice Dirac operators to the sum of the Betti numbers of the underlying spacetime manifold, we study formal naive Dirac operators on a class of graphs admitting ...
G. M. von Hippel
doaj   +1 more source

An information theoretic method for developing modular architectures using genetic algorithms

Research in Engineering Design, 2007
Designing modular products can result in many benefits to both manufacturers and consumers. The development of modular products requires the identification of highly interactive groups of elements and arranging (i.e., clustering) them into modules. However, no rigorous clustering technique can be found in engineering design literature.
Yu, Tian-Li, Yassine, Ali A., Goldberg, David E.   +2 more
openaire   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Physics-conditioned diffusion models for lattice gauge theory

Journal of High Energy Physics
We develop diffusion models for simulating lattice gauge theories, where stochastic quantization is explicitly incorporated as a physical condition for sampling. We demonstrate the applicability of this novel sampler to U(1) gauge theory in two spacetime
Qianteng Zhu, Gert Aarts, Wei Wang, Kai Zhou, Lingxiao Wang   +4 more
doaj   +1 more source

Stochastic normalizing flows as non-equilibrium transformations

Journal of High Energy Physics, 2022
Normalizing flows are a class of deep generative models that provide a promising route to sample lattice field theories more efficiently than conventional Monte Carlo simulations.
Michele Caselle, Elia Cellini, Alessandro Nada, Marco Panero   +3 more
doaj   +1 more source

Branch-and-Sandwich: a deterministic global optimization algorithm for optimistic bilevel programming problems. Part I: Theoretical development [PDF]

Journal of Global Optimization, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Polyxeni-Margarita Kleniati, Claire S. Adjiman   +1 more
openaire   +4 more sources

Parameterized Algorithms in Bioinformatics: An Overview

, 2019
International audienceBioinformatics regularly poses new challenges to algorithm engineers and theoretical computer scientists. This work surveys recent developments of parameterized algorithms and complexity for important NP-hard problems in ...
Laurent Bulteau, Bulteau, Laurent, Mathias Weller, Weller, Mathias   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source