Results 91 to 100 of about 57,258 (313)
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Outer Approximation Algorithms for DC Programs and Beyond
, 2008 We consider the well-known Canonical DC (CDC) optimization problem, relying on an alternative equivalent formulation based on a polar characterization of the constraint, and a novel generalization of this problem, which we name Single Reverse Polar ...
ZHANG, QINGHUA
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Anytime Algorithms for ROBDD Symmetry Detection and Approximation [PDF]
Reduced Ordered Binary Decision Diagrams (ROBDDs) provide a dense and memory efficient representation of Boolean functions. When ROBDDs are applied in logic synthesis, the problem arises of detecting both classical and generalised symmetries.
Kettle, Neil
core
The expressibility of functions on the Boolean domain, with applications to Counting CSPs [PDF]
, 2013 An important tool in the study of the complexity of Constraint Satisfaction Problems (CSPs) is the notion of a relational clone, which is the set of all relations expressible using primitive positive formulas over a particular set of base relations. Post'
Bulatov, AA +6 more
core +1 more source
Quantum algorithm for approximating partition functions
Physical Review A, 2009 We achieve a quantum speed-up of fully polynomial randomized approximation schemes (FPRAS) for estimating partition functions that combine simulated annealing with the Monte-Carlo Markov Chain method and use non-adaptive cooling schedules. The improvement in time complexity is twofold: a quadratic reduction with respect to the spectral gap of the ...
Wocjan, Pawel +3 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Approximation algorithm to symmetric alpha stable distribution with bi-region curve model
Tongxin xuebao, 2013 The symmetric alpha stable (S S) was used to model a non-Gaussian,heavy tail and impulsive noise of com-α munication channels.However,explicit expressions for the probability density functions (PDF) in terms of elementary functions are still unknown ...
Kang WANG, Zhi-jiang XU, Li-min MENG
doaj +2 more sources
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source