Results 71 to 80 of about 57,258 (313)

Differentiable Earth mover’s distance for data compression at the high-luminosity LHC

Machine Learning: Science and Technology, 2023
The Earth mover’s distance (EMD) is a useful metric for image recognition and classification, but its usual implementations are not differentiable or too slow to be used as a loss function for training other algorithms via gradient descent. In this paper,
Rohan Shenoy, Javier Duarte, Christian Herwig, James Hirschauer, Daniel Noonan, Maurizio Pierini, Nhan Tran, Cristina Mantilla Suarez   +7 more
doaj   +1 more source

A hybrid of Bayesian-based global search with Hooke–Jeeves local refinement for multi-objective optimization problems

Nonlinear Analysis, 2022
The proposed multi-objective optimization algorithm hybridizes random global search with a local refinement algorithm. The global search algorithm mimics the Bayesian multi-objective optimization algorithm.
Linas Litvinas
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Uncertainty quantification and weak approximation of an elliptic inverse problem [PDF]

, 2011
We consider the inverse problem of determining the permeability from the pressure in a Darcy model of flow in a porous medium. Mathematically the problem is to find the diffusion coefficient for a linear uniformly elliptic partial differential equation ...
Worthington, Claire, Robinson, Stewart, Davis, Neil D., Radnor, Zoe, Cooke, Matthew W, Burgess, Nicola, Cooke, Matthew, M. Dashti, Davies, Neil, Dashti, M., A. M. Stuart, Masoumeh Dashti (4463344), Worthington, Claire H, A M Stuart (13396491), Stuart, A. M.   +14 more
core   +1 more source

Algoritmos Wavenet con Aplicaciones en la Aproximación de Señales: un Estudio Comparativo

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2012
Resumen: En este trabajo de investigación se aplican métodos adaptables en el diseño de algoritmos computacionales, dichos algoritmos emplean redes neuronales y series de wavelets para construir “neuroaproximadores” wavenets.
C.R. Domínguez Mayorga, M.A. Espejel Rivera, L.E. Ramos Velasco, J.C. Ramos Fernández, E. Escamilla Hernández   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Finite Element Quadrature of Regularized Discontinuous and Singular Level Set Functions in 3D Problems [PDF]

, 2012
Regularized Heaviside and Dirac delta function are used in several fields of computational physics and mechanics. Hence the issue of the quadrature of integrals of discontinuous and singular functions arises.
PONARA, Nicola, Ponara, N., Ponara N., Benvenuti, E., Nicola Ponara, BENVENUTI, Elena, Ventura, Giulio, Giulio Ventura, Benvenuti E., Elena Benvenuti   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A quantum algorithm to approximate the linear structures of Boolean functions [PDF]

Mathematical Structures in Computer Science, 2016
A quantum algorithm to determine approximations of linear structures of Boolean functions is presented and analysed. Similar results have already been published (see Simon's algorithm) but only for some promise versions of the problem, and it has been shown that no exponential quantum speedup can be obtained for the general (no promise) version of the ...
Hongwei Li 0016, Li Yang
openaire   +2 more sources