Results 101 to 110 of about 522,654 (284)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou +12 more
wiley +1 more source
BMC Bioinformatics, 2007 Background Identity by descent (IBD) matrix estimation is a central component in mapping of Quantitative Trait Loci (QTL) using variance component models.
Carlborg Örjan, Besnier Francois
doaj +1 more source
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source
Influence Activation Function in Approximate Periodic Functions Using Neural Networks
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 The aim of this paper is to design fast neural networks to approximate periodic functions, that is, design a fully connected networks contains links between all nodes in adjacent layers which can speed up the approximation times, reduce approximation ...
Luma N. M. Tawfiq, Ala K. Jabber
doaj
Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams +14 more
wiley +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
A general quantum algorithm for numerical integration
Scientific ReportsQuantum algorithms have shown their superiority in many application fields. However, a general quantum algorithm for numerical integration, an indispensable tool for processing sophisticated science and engineering issues, is still missing.
Guoqiang Shu +4 more
doaj +1 more source
Laguerre-Based Frequency-Limited Balanced Truncation of Discrete-Time Systems
MathematicsThis paper introduces a novel model order reduction (MOR) method for linear discrete-time systems, focusing on frequency-limited balanced truncation (BT) techniques. By leveraging Laguerre functions, we develop two efficient MOR algorithms that avoid the
Zhou Song, Qiu-Yan Song, Umair Zulfiqar
doaj +1 more source