Results 41 to 50 of about 1,305,670 (283)
Model Reconstruction from Small-Angle X-Ray Scattering Data Using Deep Learning Methods
iScience, 2020 Summary: Small-angle X-ray scattering (SAXS) method is widely used in investigating protein structures in solution, but high-quality 3D model reconstructions are challenging.
Hao He, Can Liu, Haiguang Liu
doaj +1 more source
The Logic of Time: from Aristotle to Computer Science [PDF]
, 2017 Charla tipo conferencia-seminario dada para alumnos de un másterThis short course will explore that continuous thread which connects the discussion about time in philosophy with the modern use of temporal logic in computer science. It will go through the
Bresolin, Davide
core
Improved Parallel Rabin-Karp Algorithm Using Compute Unified Device Architecture
, 2018 String matching algorithms are among one of the most widely used algorithms in computer science. Traditional string matching algorithms efficiency of underlaying string matching algorithm will greatly increase the efficiency of any application. In recent
D Xu +6 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Machine Learning in P&C Insurance: A Review for Pricing and Reserving
Risks, 2020 In the past 25 years, computer scientists and statisticians developed machine learning algorithms capable of modeling highly nonlinear transformations and interactions of input features.
Christopher Blier-Wong +3 more
doaj +1 more source
Combinatorial Scientific Computing: The Enabling Power of Discrete Algorithms in Computational Science [PDF]
, 2007 Combinatorial algorithms have long played a crucial, albeit under-recognized role in scientific computing. This impact ranges well beyond the familiar applications of graph algorithms in sparse matrices to include mesh generation, optimization, computational biology and chemistry, data analysis and parallelization.
Bruce Hendrickson, Alex Pothen
openaire +1 more source
Aspects of Unstructured Grids and Finite-Volume Solvers for the Euler and Navier-Stokes Equations [PDF]
, 1992 One of the major achievements in engineering science has been the development of computer algorithms for solving nonlinear differential equations such as the Navier-Stokes equations.
Barth, Timothy J.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source